Integrins and their extracellular matrix ligands in gastric cancer

Y. D. Ramkissoon, R. Del Buono, I. M. Filipe, S. Buk, P. A. Hall, M. Pignatelli

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Extracellular matrix (ECM) proteins and their specific cellular receptors, play an important role in the regulation of epithelial, morphogenesis and differentiation. Alterations in their expression and function have been found in a number of malignant tumours and these changes may help to explain their dedifferentiation and altered behaviour. this study we have investigated expression and distribution of the epithelial β1 integrins (α2β1, α3β1 and α6β1) and their ECM ligands (fibronectin, tenascin and laminin) in normal and neoplastic gastric tissue. An up-regulation of two isoforms of fibronectin, and tenascin was seen in tumour associated matrix compared to normal stroma. Loss or down regulation of a integrin chains was seen more frequently in poorly differentiated carcinomas (α2 p=0.002; α3 p=0.013; α(6 p=0.0012) irrespective of tumour type (diffuse or intestinal) than in well/moderately differentiated tumours. Cell adhesion assays revealed that the ability of gastric carcinoma cell lines to bind matrix glycoproteins correlated to their degree of differentiation. Furthermore, poorly differentiated cell lines showed a down-regulation of α2 and α6 integrin expression. These data indicate that architectural and cytological differentiation in gastric carcinoma relates to altered patterns of expression of matrix glycoproteins and their receptors. The traditional Lauren classification seems to reflect these differences in cell-matrix interactions. Differing patterns of expression of those molecules involved in cellmatrix interactions may prove to be a more objective and biologically more relevant means of classifying gastric cancer.

Original languageEnglish
Pages (from-to)689-695
Number of pages7
JournalInternational Journal of Oncology
Volume5
Issue number3
Publication statusPublished - 1994
Externally publishedYes

Fingerprint

Integrins
Stomach Neoplasms
Extracellular Matrix
Ligands
Tenascin
Stomach
Carcinoma
Fibronectins
Neoplasms
Glycoproteins
Down-Regulation
Cell Line
Extracellular Matrix Proteins
Laminin
Morphogenesis
Cell Adhesion
Cell Communication
Protein Isoforms
Up-Regulation

Keywords

  • Adhesion
  • Extracellular matrix
  • Integrins
  • Stomach

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ramkissoon, Y. D., Del Buono, R., Filipe, I. M., Buk, S., Hall, P. A., & Pignatelli, M. (1994). Integrins and their extracellular matrix ligands in gastric cancer. International Journal of Oncology, 5(3), 689-695.

Integrins and their extracellular matrix ligands in gastric cancer. / Ramkissoon, Y. D.; Del Buono, R.; Filipe, I. M.; Buk, S.; Hall, P. A.; Pignatelli, M.

In: International Journal of Oncology, Vol. 5, No. 3, 1994, p. 689-695.

Research output: Contribution to journalArticle

Ramkissoon, YD, Del Buono, R, Filipe, IM, Buk, S, Hall, PA & Pignatelli, M 1994, 'Integrins and their extracellular matrix ligands in gastric cancer', International Journal of Oncology, vol. 5, no. 3, pp. 689-695.
Ramkissoon YD, Del Buono R, Filipe IM, Buk S, Hall PA, Pignatelli M. Integrins and their extracellular matrix ligands in gastric cancer. International Journal of Oncology. 1994;5(3):689-695.
Ramkissoon, Y. D. ; Del Buono, R. ; Filipe, I. M. ; Buk, S. ; Hall, P. A. ; Pignatelli, M. / Integrins and their extracellular matrix ligands in gastric cancer. In: International Journal of Oncology. 1994 ; Vol. 5, No. 3. pp. 689-695.
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