Intra-tissue pressure measurement in ex vivo liver undergoing laser ablation with fiber-optic fabry-perot probe

Daniele Tosi, Paola Saccomandi, Emiliano Schena, Dinesh Babu Duraibabu, Sven Poeggel, Gabriel Leen, Elfed Lewis

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We report the first-ever intra-tissue pressure measurement performed during 1064 nm laser ablation (LA) of an ex vivo porcine liver. Pressure detection has been performed with a biocompatible, all-glass, temperature-insensitive Extrinsic Fabry-Perot Interferometry (EFPI) miniature probe; the proposed methodology mimics in-vivo treatment. Four experiments have been performed, positioning the probe at different positions from the laser applicator tip (from 0.5 mm to 5 mm). Pressure levels increase during ablation time, and decrease with distance from applicator tip: the recorded peak parenchymal pressure levels range from 1.9 kPa to 71.6 kPa. Different pressure evolutions have been recorded, as pressure rises earlier in proximity of the tip. The present study is the first investigation of parenchymal pressure detection in liver undergoing LA: the successful detection of intra-tissue pressure may be a key asset for improving LA, as pressure levels have been correlated to scattered recurrences of tumors by different studies.

Original languageEnglish
Article number544
JournalSensors (Switzerland)
Volume16
Issue number4
DOIs
Publication statusPublished - Apr 15 2016

Fingerprint

Laser Therapy
Laser ablation
pressure measurement
Pressure measurement
liver
Liver
Fiber optics
laser ablation
fiber optics
Tissue
Pressure
probes
Applicators
Interferometry
Ablation
ablation
positioning
proximity
Tumors
interferometry

Keywords

  • Ablation of tissue
  • Fabry-Perot
  • Fiber optic sensors
  • Pressure measurement

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Atomic and Molecular Physics, and Optics
  • Analytical Chemistry
  • Biochemistry

Cite this

Intra-tissue pressure measurement in ex vivo liver undergoing laser ablation with fiber-optic fabry-perot probe. / Tosi, Daniele; Saccomandi, Paola; Schena, Emiliano; Duraibabu, Dinesh Babu; Poeggel, Sven; Leen, Gabriel; Lewis, Elfed.

In: Sensors (Switzerland), Vol. 16, No. 4, 544, 15.04.2016.

Research output: Contribution to journalArticle

Tosi, Daniele ; Saccomandi, Paola ; Schena, Emiliano ; Duraibabu, Dinesh Babu ; Poeggel, Sven ; Leen, Gabriel ; Lewis, Elfed. / Intra-tissue pressure measurement in ex vivo liver undergoing laser ablation with fiber-optic fabry-perot probe. In: Sensors (Switzerland). 2016 ; Vol. 16, No. 4.
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