Introduction of new Tumor Marker Age Score in clinical practice: Validity evaluation for differentiation benign from malignant adnexal masses.

Ivana Likić Ladjević, Milan Terzić, Nebojsa Ladjević, Jelena Dotlić, Igor Pilić, Jovan Bila, Nebojsa Knezević, Svetlana Milenković, Sanja Maricić, Nebojsa Arsenović, Natasa Brndusić, Branka Nikolić

Research output: Contribution to journalArticle

Abstract

The aim of the study was to examine several tumor markers and their correlation with pathohistological findings in patients with adnexal masses. Study involved 139 patients, 84 of them with benign, 47 with malignant and 8 with borderline adnexal tumor. Levels of CA 125, CA 19-9, CEA and CA 15-3 were obtained preoperatively and assessed regarding the specific pathohistological diagnose and the patient's age. Obtaining these results led us to divide the patient's CA 125 levels with age and by doing that we have attained a new Tumor Marker Age score (TMA score). Patients with malignant adnexal tumors had significantly higher levels of CEA (p<0.05), CA 125, CA 19-9 and CA 15-3 tumor markers (p<0.01), in comparison with patients with benign tumors. TMA score highly statistically correlate with the tumor type (benignant/malignant). With the increase of tumor marker levels and the patient's age the malignant nature of adnexal tumors is more often. Results of our study highlight the importance of the use of combined tumor markers (at least CA-125 and CA 19-9) in women with adnexal masses. Those levels along with the patient's age and new TMA score could preoperatively predict malignant nature of the tumor.

Original languageEnglish
Pages (from-to)49-56
Number of pages8
JournalActa chirurgica Iugoslavica
Volume59
Issue number3
Publication statusPublished - Dec 1 2012

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Tumor Biomarkers
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

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Introduction of new Tumor Marker Age Score in clinical practice : Validity evaluation for differentiation benign from malignant adnexal masses. / Ladjević, Ivana Likić; Terzić, Milan; Ladjević, Nebojsa; Dotlić, Jelena; Pilić, Igor; Bila, Jovan; Knezević, Nebojsa; Milenković, Svetlana; Maricić, Sanja; Arsenović, Nebojsa; Brndusić, Natasa; Nikolić, Branka.

In: Acta chirurgica Iugoslavica, Vol. 59, No. 3, 01.12.2012, p. 49-56.

Research output: Contribution to journalArticle

Ladjević, IL, Terzić, M, Ladjević, N, Dotlić, J, Pilić, I, Bila, J, Knezević, N, Milenković, S, Maricić, S, Arsenović, N, Brndusić, N & Nikolić, B 2012, 'Introduction of new Tumor Marker Age Score in clinical practice: Validity evaluation for differentiation benign from malignant adnexal masses.', Acta chirurgica Iugoslavica, vol. 59, no. 3, pp. 49-56.
Ladjević, Ivana Likić ; Terzić, Milan ; Ladjević, Nebojsa ; Dotlić, Jelena ; Pilić, Igor ; Bila, Jovan ; Knezević, Nebojsa ; Milenković, Svetlana ; Maricić, Sanja ; Arsenović, Nebojsa ; Brndusić, Natasa ; Nikolić, Branka. / Introduction of new Tumor Marker Age Score in clinical practice : Validity evaluation for differentiation benign from malignant adnexal masses. In: Acta chirurgica Iugoslavica. 2012 ; Vol. 59, No. 3. pp. 49-56.
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