Investigation of thermal effects of radiofrequency ablation mediated with iron oxide nanoparticles dispersed in agarose and chitosan solvents

Zhannat Ashikbaeva, Arman Aitkulov, Alexey Wolf, Alexander Dostovalov, Aida Amantayeva, Aliya Kurbanova, Vasileios Inglezakis, Daniele Tosi

Research output: Contribution to journalArticlepeer-review

Abstract

Thermal ablation (TA) is known as an alternative therapy to surgery to treat tumors. However, TA-based therapy requires advanced approaches in order to prevent causing damage to healthy tissue around the tumor and selectively target the desired area. Nanoparticles are considered as a promising tool in biomedicine to fulfill these requirements. This study was carried out in order to analyze the effect of iron oxide nanoparticles on the temperature increment during radiofrequency ablation therapy of porcine liver. In addition, this research aimed to experimentally evaluate the impact of two solvents such as agarose and chitosan on the temperature change, when magnetic nanoparticles were dispersed in them. The iron oxide nanoparticles were synthesized by the solvothermal method demonstrating the magnetic properties by acting to the external magnetic field. To increase the local heat superparamagnetic nanoparticles (iron oxide magnetic nanoparticle (IONPs)) of the average size of 20 nm in size and the concentrations from 1 to 10 mg/mL of MNPs with a step size of 1 mg/mL were tested in 10 replicates for each concentration and solvent. Moreover, the temperature changes for dry liver, and 0 mg/mL concentration was checked for calibration and reference purposes. As a sensing system, advanced 16-FBG optical fiber sensors connected to an interrogator were employed allowing the temperature change to be monitored accurately in real time. A maximum temperature of about 142 C was recorded by a 5 mg/mL concentration of iron oxide nanoparticles dispersed in the agarose solvent.

Original languageEnglish
Article number2437
JournalApplied Sciences (Switzerland)
Volume11
Issue number5
DOIs
Publication statusPublished - Mar 1 2021

Keywords

  • Fiber Bragg grating (FBG)
  • Iron oxide magnetic nanoparticles
  • Optical fiber
  • Radiofrequency ablation
  • The sensing system

ASJC Scopus subject areas

  • Materials Science(all)
  • Instrumentation
  • Engineering(all)
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes

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