Ischemia modified albumin and acute kidney injury in pump-on cardiac surgery

Gaipov A., Turkmen K., Toker A., Solak Y., Cicekler H., Ucar R., Kilicaslan A., Gormus N., Tonbul H.Z., Yeksan M., Turk S.

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Introduction and Aims: Neutrophil gelatinase-associated lipocalin (NGAL) is one of the biomarkers of acute kidney injury (AKI). Ischemia Modified Albumin (IMA) is a new marker used to detect acute ischemic events. The aim of our study was to determine the role of IMA in the development of AKI and/or is IMA a marker of AKI in patients undergoing pump-on cardiac surgery. Methods: This is a prospective study of patients who were underwent pump-on cardiac surgery due to coronary artery bypass grafting and/or cardiac valve surgery. AKI defined according to KDIGO AKI guideline. Blood samples for measurement of IMA, NGAL and creatinin levels were collected prior to cardiac surgery (0h) and in the time course on 2nd, 12th and 24th hours after conducted surgery (2h 12h and 24h respectively), and neutrophil-to-lymphocyte ratio (NLR) was calculated from hemogram as well. Patients with developed AKI were divided in to two subgroups that had non progressed and progressed AKI. Criteria for progression of AKI included: the transition from the I stage to the II or III, from the II stage to the III stage and the beginning of CRRT. Results: Fourty eight patients (31 male, 17 female) were included to the study. After cardiac surgery 33 patients developed any stage of AKI, 22 of them non-progressed AKI, 11 - progressed AKI. The basal characteristics of patients showed in table. All of the markers significantly increased after cardiac surgery, but IMA and NLR levels not differed between groups. ROC analysis of 2nd hours markers showed that NGAL and creatinin had significantly large area under the curve (AUC) than IMA and NLR to predict AKI developed at 24 hours. Conclusions: IMA as well as NLR increased after cardiac surgery, but not predicted development of AKI. (Table presented).
Original languageEnglish
Title of host publicationNephrology Dialysis Transplantation
Publication statusPublished - 2013

Publication series

NameNephrology Dialysis Transplantation

Fingerprint

Acute Kidney Injury
Thoracic Surgery
Neutrophils
Lymphocytes
ischemia-modified albumin
Heart Valves
Coronary Artery Bypass
ROC Curve
Area Under Curve
Biomarkers
Prospective Studies
Guidelines

Keywords

  • *acute kidney failure
  • *edetic acid
  • *heart surgery
  • *ischemia modified albumin
  • *pump
  • area under the curve
  • blood sampling
  • continuous renal replacement therapy
  • coronary artery bypass graft
  • creatinine
  • female
  • heart valve
  • human
  • lymphocyte
  • male
  • marker
  • neutrophil
  • neutrophil gelatinase associated lipocalin
  • patient
  • prospective study
  • receiver operating characteristic
  • surgery

Cite this

A., G., K., T., A., T., Y., S., H., C., R., U., ... S., T. (2013). Ischemia modified albumin and acute kidney injury in pump-on cardiac surgery. In Nephrology Dialysis Transplantation (Nephrology Dialysis Transplantation).

Ischemia modified albumin and acute kidney injury in pump-on cardiac surgery. / A., Gaipov; K., Turkmen; A., Toker; Y., Solak; H., Cicekler; R., Ucar; A., Kilicaslan; N., Gormus; H.Z., Tonbul; M., Yeksan; S., Turk.

Nephrology Dialysis Transplantation. 2013. (Nephrology Dialysis Transplantation).

Research output: Chapter in Book/Report/Conference proceedingChapter

A., G, K., T, A., T, Y., S, H., C, R., U, A., K, N., G, H.Z., T, M., Y & S., T 2013, Ischemia modified albumin and acute kidney injury in pump-on cardiac surgery. in Nephrology Dialysis Transplantation. Nephrology Dialysis Transplantation.
A. G, K. T, A. T, Y. S, H. C, R. U et al. Ischemia modified albumin and acute kidney injury in pump-on cardiac surgery. In Nephrology Dialysis Transplantation. 2013. (Nephrology Dialysis Transplantation).
A., Gaipov ; K., Turkmen ; A., Toker ; Y., Solak ; H., Cicekler ; R., Ucar ; A., Kilicaslan ; N., Gormus ; H.Z., Tonbul ; M., Yeksan ; S., Turk. / Ischemia modified albumin and acute kidney injury in pump-on cardiac surgery. Nephrology Dialysis Transplantation. 2013. (Nephrology Dialysis Transplantation).
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abstract = "Introduction and Aims: Neutrophil gelatinase-associated lipocalin (NGAL) is one of the biomarkers of acute kidney injury (AKI). Ischemia Modified Albumin (IMA) is a new marker used to detect acute ischemic events. The aim of our study was to determine the role of IMA in the development of AKI and/or is IMA a marker of AKI in patients undergoing pump-on cardiac surgery. Methods: This is a prospective study of patients who were underwent pump-on cardiac surgery due to coronary artery bypass grafting and/or cardiac valve surgery. AKI defined according to KDIGO AKI guideline. Blood samples for measurement of IMA, NGAL and creatinin levels were collected prior to cardiac surgery (0h) and in the time course on 2nd, 12th and 24th hours after conducted surgery (2h 12h and 24h respectively), and neutrophil-to-lymphocyte ratio (NLR) was calculated from hemogram as well. Patients with developed AKI were divided in to two subgroups that had non progressed and progressed AKI. Criteria for progression of AKI included: the transition from the I stage to the II or III, from the II stage to the III stage and the beginning of CRRT. Results: Fourty eight patients (31 male, 17 female) were included to the study. After cardiac surgery 33 patients developed any stage of AKI, 22 of them non-progressed AKI, 11 - progressed AKI. The basal characteristics of patients showed in table. All of the markers significantly increased after cardiac surgery, but IMA and NLR levels not differed between groups. ROC analysis of 2nd hours markers showed that NGAL and creatinin had significantly large area under the curve (AUC) than IMA and NLR to predict AKI developed at 24 hours. Conclusions: IMA as well as NLR increased after cardiac surgery, but not predicted development of AKI. (Table presented).",
keywords = "*acute kidney failure, *edetic acid, *heart surgery, *ischemia modified albumin, *pump, area under the curve, blood sampling, continuous renal replacement therapy, coronary artery bypass graft, creatinine, female, heart valve, human, lymphocyte, male, marker, neutrophil, neutrophil gelatinase associated lipocalin, patient, prospective study, receiver operating characteristic, surgery",
author = "Gaipov A. and Turkmen K. and Toker A. and Solak Y. and Cicekler H. and Ucar R. and Kilicaslan A. and Gormus N. and Tonbul H.Z. and Yeksan M. and Turk S.",
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TY - CHAP

T1 - Ischemia modified albumin and acute kidney injury in pump-on cardiac surgery

AU - A., Gaipov

AU - K., Turkmen

AU - A., Toker

AU - Y., Solak

AU - H., Cicekler

AU - R., Ucar

AU - A., Kilicaslan

AU - N., Gormus

AU - H.Z., Tonbul

AU - M., Yeksan

AU - S., Turk

PY - 2013

Y1 - 2013

N2 - Introduction and Aims: Neutrophil gelatinase-associated lipocalin (NGAL) is one of the biomarkers of acute kidney injury (AKI). Ischemia Modified Albumin (IMA) is a new marker used to detect acute ischemic events. The aim of our study was to determine the role of IMA in the development of AKI and/or is IMA a marker of AKI in patients undergoing pump-on cardiac surgery. Methods: This is a prospective study of patients who were underwent pump-on cardiac surgery due to coronary artery bypass grafting and/or cardiac valve surgery. AKI defined according to KDIGO AKI guideline. Blood samples for measurement of IMA, NGAL and creatinin levels were collected prior to cardiac surgery (0h) and in the time course on 2nd, 12th and 24th hours after conducted surgery (2h 12h and 24h respectively), and neutrophil-to-lymphocyte ratio (NLR) was calculated from hemogram as well. Patients with developed AKI were divided in to two subgroups that had non progressed and progressed AKI. Criteria for progression of AKI included: the transition from the I stage to the II or III, from the II stage to the III stage and the beginning of CRRT. Results: Fourty eight patients (31 male, 17 female) were included to the study. After cardiac surgery 33 patients developed any stage of AKI, 22 of them non-progressed AKI, 11 - progressed AKI. The basal characteristics of patients showed in table. All of the markers significantly increased after cardiac surgery, but IMA and NLR levels not differed between groups. ROC analysis of 2nd hours markers showed that NGAL and creatinin had significantly large area under the curve (AUC) than IMA and NLR to predict AKI developed at 24 hours. Conclusions: IMA as well as NLR increased after cardiac surgery, but not predicted development of AKI. (Table presented).

AB - Introduction and Aims: Neutrophil gelatinase-associated lipocalin (NGAL) is one of the biomarkers of acute kidney injury (AKI). Ischemia Modified Albumin (IMA) is a new marker used to detect acute ischemic events. The aim of our study was to determine the role of IMA in the development of AKI and/or is IMA a marker of AKI in patients undergoing pump-on cardiac surgery. Methods: This is a prospective study of patients who were underwent pump-on cardiac surgery due to coronary artery bypass grafting and/or cardiac valve surgery. AKI defined according to KDIGO AKI guideline. Blood samples for measurement of IMA, NGAL and creatinin levels were collected prior to cardiac surgery (0h) and in the time course on 2nd, 12th and 24th hours after conducted surgery (2h 12h and 24h respectively), and neutrophil-to-lymphocyte ratio (NLR) was calculated from hemogram as well. Patients with developed AKI were divided in to two subgroups that had non progressed and progressed AKI. Criteria for progression of AKI included: the transition from the I stage to the II or III, from the II stage to the III stage and the beginning of CRRT. Results: Fourty eight patients (31 male, 17 female) were included to the study. After cardiac surgery 33 patients developed any stage of AKI, 22 of them non-progressed AKI, 11 - progressed AKI. The basal characteristics of patients showed in table. All of the markers significantly increased after cardiac surgery, but IMA and NLR levels not differed between groups. ROC analysis of 2nd hours markers showed that NGAL and creatinin had significantly large area under the curve (AUC) than IMA and NLR to predict AKI developed at 24 hours. Conclusions: IMA as well as NLR increased after cardiac surgery, but not predicted development of AKI. (Table presented).

KW - acute kidney failure

KW - edetic acid

KW - heart surgery

KW - ischemia modified albumin

KW - pump

KW - area under the curve

KW - blood sampling

KW - continuous renal replacement therapy

KW - coronary artery bypass graft

KW - creatinine

KW - female

KW - heart valve

KW - human

KW - lymphocyte

KW - male

KW - marker

KW - neutrophil

KW - neutrophil gelatinase associated lipocalin

KW - patient

KW - prospective study

KW - receiver operating characteristic

KW - surgery

UR - http://www.mendeley.com/research/ischemia-modified-albumin-acute-kidney-injury-pumpon-cardiac-surgery

M3 - Chapter

SN - 0931-0509

T3 - Nephrology Dialysis Transplantation

BT - Nephrology Dialysis Transplantation

ER -