Kinetic dependence of paramyxovirus entry inhibition

Matteo Porotto, Christine C. Yokoyama, Gianmarco Orefice, Han Sung Kim, Mohamed Aljofan, Bruce A. Mungall, Anne Moscona

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Peptides derived from conserved heptad repeat (HR) regions of paramyxovirus fusion (F) proteins inhibit viral fusion by interfering with the formation of the fusogenic six-helix bundle structure. Peptide efficacy is affected by the strength of the peptide association with the target virus's complementary HR region. Here, we show that a second basis for peptide efficacy lies in the kinetics of F activation by the homotypic attachment protein: efficient F activation by the attachment protein shortens the period during which antiviral molecules targeting intermediate states of F may act, thereby modulating the effectiveness of inhibitory peptides. These results highlight new issues to be considered in developing strategies for fusion inhibitors.

Original languageEnglish
Pages (from-to)6947-6951
Number of pages5
JournalJournal of Virology
Volume83
Issue number13
DOIs
Publication statusPublished - Jul 1 2009
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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