Kolbe Anodic Decarboxylation as a Green Way to Access 2-Pyrrolidinones

Mathilde Quertenmont, Iain Goodall, Kevin Lam, István Markó, Olivier Riant

Research output: Contribution to journalArticle

Abstract

Nootropic compounds are a group of pharmacologically active pyrrolidones. These molecules, which enhance cognition properties and possess a large prescription field, are particularly interesting synthetic targets for the pharmaceutical industry. In this Article, we disclose an effective and environmentally friendly pyrrolidinone synthesis using electrosynthesis. The newly developed methodology includes a Kolbe decarboxylation, followed by an intramolecular radical cyclization and a radical-radical cross-coupling.

Original languageEnglish
JournalOrganic Letters
DOIs
Publication statusAccepted/In press - Jan 1 2020

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Quertenmont, M., Goodall, I., Lam, K., Markó, I., & Riant, O. (Accepted/In press). Kolbe Anodic Decarboxylation as a Green Way to Access 2-Pyrrolidinones. Organic Letters. https://doi.org/10.1021/acs.orglett.0c00056