Kolbe Anodic Decarboxylation as a Green Way to Access 2-Pyrrolidinones

Mathilde Quertenmont, Iain Goodall, Kevin Lam, István Markó, Olivier Riant

Research output: Contribution to journalArticlepeer-review

Abstract

Nootropic compounds are a group of pharmacologically active pyrrolidones. These molecules, which enhance cognition properties and possess a large prescription field, are particularly interesting synthetic targets for the pharmaceutical industry. In this Article, we disclose an effective and environmentally friendly pyrrolidinone synthesis using electrosynthesis. The newly developed methodology includes a Kolbe decarboxylation, followed by an intramolecular radical cyclization and a radical-radical cross-coupling.

Original languageEnglish
JournalOrganic Letters
DOIs
Publication statusAccepted/In press - Jan 1 2020

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Kolbe Anodic Decarboxylation as a Green Way to Access 2-Pyrrolidinones'. Together they form a unique fingerprint.

Cite this