Kolbe Anodic Decarboxylation as a Green Way to Access 2-Pyrrolidinones

Mathilde Quertenmont, Iain Goodall, Kevin Lam, István Markó, Olivier Riant

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Nootropic compounds are a group of pharmacologically active pyrrolidones. These molecules, which enhance cognition properties and possess a large prescription field, are particularly interesting synthetic targets for the pharmaceutical industry. In this Article, we disclose an effective and environmentally friendly pyrrolidinone synthesis using electrosynthesis. The newly developed methodology includes a Kolbe decarboxylation, followed by an intramolecular radical cyclization and a radical-radical cross-coupling.

Original languageEnglish
Pages (from-to)1771-1775
Number of pages5
JournalOrganic Letters
Issue number5
Publication statusPublished - Mar 6 2020

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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