Lack of Conventional Dendritic Cells Is Compatible with Normal Development and T Cell Homeostasis, but Causes Myeloid Proliferative Syndrome

Tal Birnberg, Liat Bar-On, Anita Sapoznikov, Michele L. Caton, Luisa Cervantes-Barragán, Divine Makia, Rita Krauthgamer, Ori Brenner, Burkhard Ludewig, Damian Brockschnieder, Dieter Riethmacher, Boris Reizis, Steffen Jung

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

Dendritic cells are critically involved in the promotion and regulation of T cell responses. Here, we report a mouse strain that lacks conventional CD11chi dendritic cells (cDCs) because of constitutive cell-type specific expression of a suicide gene. As expected, cDC-less mice failed to mount effective T cell responses resulting in impaired viral clearance. In contrast, neither thymic negative selection nor T regulatory cell generation or T cell homeostasis were markedly affected. Unexpectedly, cDC-less mice developed a progressive myeloproliferative disorder characterized by prominent extramedullary hematopoiesis and increased serum amounts of the cytokine Flt3 ligand. Our data identify a critical role of cDCs in the control of steady-state hematopoiesis, revealing a feedback loop that links peripheral cDCs to myelogenesis through soluble growth factors, such as Flt3 ligand.

Original languageEnglish
Pages (from-to)986-997
Number of pages12
JournalImmunity
Volume29
Issue number6
DOIs
Publication statusPublished - Dec 19 2008
Externally publishedYes

Fingerprint

Dendritic Cells
Homeostasis
T-Lymphocytes
Extramedullary Hematopoiesis
Myeloproliferative Disorders
Hematopoiesis
Regulatory T-Lymphocytes
Suicide
Intercellular Signaling Peptides and Proteins
Cytokines
Serum
Genes
flt3 ligand protein

Keywords

  • MOLIMMUNO

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Birnberg, T., Bar-On, L., Sapoznikov, A., Caton, M. L., Cervantes-Barragán, L., Makia, D., ... Jung, S. (2008). Lack of Conventional Dendritic Cells Is Compatible with Normal Development and T Cell Homeostasis, but Causes Myeloid Proliferative Syndrome. Immunity, 29(6), 986-997. https://doi.org/10.1016/j.immuni.2008.10.012

Lack of Conventional Dendritic Cells Is Compatible with Normal Development and T Cell Homeostasis, but Causes Myeloid Proliferative Syndrome. / Birnberg, Tal; Bar-On, Liat; Sapoznikov, Anita; Caton, Michele L.; Cervantes-Barragán, Luisa; Makia, Divine; Krauthgamer, Rita; Brenner, Ori; Ludewig, Burkhard; Brockschnieder, Damian; Riethmacher, Dieter; Reizis, Boris; Jung, Steffen.

In: Immunity, Vol. 29, No. 6, 19.12.2008, p. 986-997.

Research output: Contribution to journalArticle

Birnberg, T, Bar-On, L, Sapoznikov, A, Caton, ML, Cervantes-Barragán, L, Makia, D, Krauthgamer, R, Brenner, O, Ludewig, B, Brockschnieder, D, Riethmacher, D, Reizis, B & Jung, S 2008, 'Lack of Conventional Dendritic Cells Is Compatible with Normal Development and T Cell Homeostasis, but Causes Myeloid Proliferative Syndrome', Immunity, vol. 29, no. 6, pp. 986-997. https://doi.org/10.1016/j.immuni.2008.10.012
Birnberg, Tal ; Bar-On, Liat ; Sapoznikov, Anita ; Caton, Michele L. ; Cervantes-Barragán, Luisa ; Makia, Divine ; Krauthgamer, Rita ; Brenner, Ori ; Ludewig, Burkhard ; Brockschnieder, Damian ; Riethmacher, Dieter ; Reizis, Boris ; Jung, Steffen. / Lack of Conventional Dendritic Cells Is Compatible with Normal Development and T Cell Homeostasis, but Causes Myeloid Proliferative Syndrome. In: Immunity. 2008 ; Vol. 29, No. 6. pp. 986-997.
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