Abstract
A study of villus samples from eight random sites on five electively aborted chorion sacs was performed to determine any significant differences in yield, quality and composition of DNA, iduronate sulphate sulphatase activity and karyotype status. The villi were also examined for their histological characteristics (e.g. stem, intermediate or terminal villi) and for HCG and BGP immuno-reactivities. The overall findings indicated no significant site to site variations in any of the parameters studied. It is therefore proposed that any villus should be equally suitable for prenatal diagnosis.
| Original language | English |
|---|---|
| Pages (from-to) | 119-127 |
| Number of pages | 9 |
| Journal | Prenatal Diagnosis |
| Volume | 7 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics(clinical)
- Obstetrics and Gynaecology
Cite this
Lack of sampling site variation in chorion villus biopsy as assessed by DNA, enzymatic, morphological and cytogenetical analyses. / Upadhyaya, M.; Jasani, B.; Little, E.; Harper, P. S.; Rees, D.; Roberts, A.
In: Prenatal Diagnosis, Vol. 7, No. 2, 1987, p. 119-127.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lack of sampling site variation in chorion villus biopsy as assessed by DNA, enzymatic, morphological and cytogenetical analyses
AU - Upadhyaya, M.
AU - Jasani, B.
AU - Little, E.
AU - Harper, P. S.
AU - Rees, D.
AU - Roberts, A.
PY - 1987
Y1 - 1987
N2 - A study of villus samples from eight random sites on five electively aborted chorion sacs was performed to determine any significant differences in yield, quality and composition of DNA, iduronate sulphate sulphatase activity and karyotype status. The villi were also examined for their histological characteristics (e.g. stem, intermediate or terminal villi) and for HCG and BGP immuno-reactivities. The overall findings indicated no significant site to site variations in any of the parameters studied. It is therefore proposed that any villus should be equally suitable for prenatal diagnosis.
AB - A study of villus samples from eight random sites on five electively aborted chorion sacs was performed to determine any significant differences in yield, quality and composition of DNA, iduronate sulphate sulphatase activity and karyotype status. The villi were also examined for their histological characteristics (e.g. stem, intermediate or terminal villi) and for HCG and BGP immuno-reactivities. The overall findings indicated no significant site to site variations in any of the parameters studied. It is therefore proposed that any villus should be equally suitable for prenatal diagnosis.
UR - http://www.scopus.com/inward/record.url?scp=0023126350&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023126350&partnerID=8YFLogxK
U2 - 10.1002/pd.1970070208
DO - 10.1002/pd.1970070208
M3 - Article
VL - 7
SP - 119
EP - 127
JO - Prenatal Diagnosis
JF - Prenatal Diagnosis
SN - 0197-3851
IS - 2
ER -