Lack of sampling site variation in chorion villus biopsy as assessed by DNA, enzymatic, morphological and cytogenetical analyses

M. Upadhyaya, B. Jasani, E. Little, P. S. Harper, D. Rees, A. Roberts

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

A study of villus samples from eight random sites on five electively aborted chorion sacs was performed to determine any significant differences in yield, quality and composition of DNA, iduronate sulphate sulphatase activity and karyoptype status. The villi were also examined for their histological characteristics (e.g. stem, intermediate or terminal villi) and for HCG and BGP immuno‐reactivities. The overall findings indicated no significant site to site variations in any of the parameters studied. It is therefore proposed that any villus should be equally suitable for prenatal diagnosis.

Original languageEnglish
Pages (from-to)119-127
Number of pages9
JournalPrenatal Diagnosis
Volume7
Issue number2
DOIs
Publication statusPublished - Feb 1987
Externally publishedYes

Keywords

  • Chorionic villus sampling
  • DNA
  • Prenatal diagnosis

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Genetics(clinical)

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