This chapter gives a brief review and discusses the applications of the laser Doppler perfusion imaging (LDPI) technique and its role in clinical diagnosis of cancer. The LDPI systems are of tremendous value in burn assessment. Burn wounds affect the blood perfusion and high blood perfusion within a burn site signifies intact dermal perfusion and intact microvascular networks. For areas of third-degree burn with severely damaged microvascular networks, blood perfusion is dramatically decreased. The wavelength of the laser beam used in burn assessment is normally ∼633 nm. This wavelength allows detection of superficial blood vessels within a depth of ∼1-2 mm. Wavelength of ∼830 nm is less prone to absorption, and backscattering from the skin could be used to detect deeper dermal and subdermal vessels. LDPI is employed in assisting health-care management. For example, LDPI can detect hyperemic areas associated with injury and inflammation with greater sensitivity than thermally-based methods and it can also be used in the assessment of drug therapy and other forms of alternative medicine. The LDPI has great potential in a variety of several medical applications. The technique is applied mainly to study the blood perfusion of tissues near the skin surface. The LDPI measurements can complement other imaging techniques such as mammography. To add value to the diagnosis, the LDPI images could also be used for the automatic matching of similar cases previously encountered by other doctors so that relevant past treatment programs could be retrieved to help establish the prescription to the current case. This would require research into the development of an intelligent management system for LDPI images.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)