TY - JOUR
T1 - LASU
T2 - An efficient and stable phthalocyanine dye with tolerable safety profile for self-disinfecting anti-COVID textiles activated by ambient light
AU - Efimov, Alexander
AU - Dagallier, Christophe
AU - Frochot, Céline
AU - Myrzakhmetov, Bauyrzhan
AU - Arnoux, Philippe
AU - Heinonen, Tuula
AU - Mannerström, Marika
AU - Toimela, Tarja
AU - Ahmed, Zafar
AU - Audibert, Jean Frédéric
AU - Habermeyer, Benoit
AU - Mordon, Serge
AU - Pansu, Robert Bernard
N1 - Publisher Copyright:
© 2024
PY - 2024/2
Y1 - 2024/2
N2 - Background: Recent COVID crisis has demonstrated that modern society urgently needs an accessible protection against mass infections, especially viruses, as the new strains are appearing at an ever-increasing pace and cause severe harm to the population and the world economy. Methods: We have developed an efficient phthalocyanine photosensitizer LASU, that is suitable for dyeing textiles and allows to prepare reusable self-disinfecting fabrics with strong antiviral properties. The safety profile of LASU was evaluated in accredited laboratories by several in vitro assays according to the OECD-guidelines. Results: The textiles impregnated with LASU phthalocyanine showed a significant antiviral photodynamic effect even under moderate indoor and outdoor light. The dye did not show any genotoxic potential in human lymphocyte micronucleus assay. It showed a possible indication for eye irritation in human EpiOcular™ model and was phototoxic when tested in mouse BALB/c 3T3 cell test in the presence and absence of UVA-irradiation. Conclusion: Novel phthalocyanine-dyed textiles are suitable for general use as self-disinfecting antiviral barriers and materials in hospitals, households, and public places. The safety profile of LASU is the phototoxic effect which is related to LASU´s mode of action.
AB - Background: Recent COVID crisis has demonstrated that modern society urgently needs an accessible protection against mass infections, especially viruses, as the new strains are appearing at an ever-increasing pace and cause severe harm to the population and the world economy. Methods: We have developed an efficient phthalocyanine photosensitizer LASU, that is suitable for dyeing textiles and allows to prepare reusable self-disinfecting fabrics with strong antiviral properties. The safety profile of LASU was evaluated in accredited laboratories by several in vitro assays according to the OECD-guidelines. Results: The textiles impregnated with LASU phthalocyanine showed a significant antiviral photodynamic effect even under moderate indoor and outdoor light. The dye did not show any genotoxic potential in human lymphocyte micronucleus assay. It showed a possible indication for eye irritation in human EpiOcular™ model and was phototoxic when tested in mouse BALB/c 3T3 cell test in the presence and absence of UVA-irradiation. Conclusion: Novel phthalocyanine-dyed textiles are suitable for general use as self-disinfecting antiviral barriers and materials in hospitals, households, and public places. The safety profile of LASU is the phototoxic effect which is related to LASU´s mode of action.
KW - Antiviral
KW - Photodynamic antimicrobial chemotherapy
KW - Photodynamic therapy
KW - Phthalocyanine
KW - Self-disinfecting textile
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UR - http://www.scopus.com/inward/citedby.url?scp=85185183472&partnerID=8YFLogxK
U2 - 10.1016/j.pdpdt.2024.103978
DO - 10.1016/j.pdpdt.2024.103978
M3 - Article
C2 - 38237650
AN - SCOPUS:85185183472
SN - 1572-1000
VL - 45
JO - Photodiagnosis and Photodynamic Therapy
JF - Photodiagnosis and Photodynamic Therapy
M1 - 103978
ER -