Linearly chirped fiber Bragg grating response to thermal gradient: from bench tests to the real-time assessment during in vivo laser ablations of biological tissue

P. Saccomandi, Sanzhar Korganbayev, A. Varalda , R. Gassino, Daniele Tosi, C. Massaroni, M.A. Caponero, R Pop, G Perrone, M Diana, A Vallan, G Costamagna, J Marescaux, E Schena

Research output: Contribution to journalArticle

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Abstract

The response of a fiber optic sensor [linearly chirped fiber Bragg grating (LCFBG)] to a linear thermal gradient applied on its sensing length (i.e., 1.5 cm) has been investigated. After these bench tests, we assessed their feasibility for temperature monitoring during thermal tumor treatment. In particular, we performed experiments during ex vivo laser ablation (LA) in pig liver and in vivo thermal ablation in animal models (pigs). We investigated the following: (i) the relationship between the full width at half maximum of the LCFBG spectrum and the temperature difference among the extremities of the LCFBG and (ii) the relationship between the mean spectrum wavelength and the mean temperature acting on the LCFBG sensing area. These relationships showed a linear trend during both bench tests and LA in animal models. Thermal sensitivity was significant although different values were found with regards to bench tests and animal experiments. The linear trend and significant sensitivity allow hypothesizing a future use of this kind of sensor to monitor both temperature gradient and mean temperature within a tissue undergoing thermal treatment.
Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalJournal of Biomedical Optics
Volume22
Issue number9
Publication statusPublished - Sep 2017

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Laser ablation
Fiber Bragg gratings
Thermal gradients
Bragg gratings
seats
laser ablation
Tissue
gradients
Animals
animal models
fibers
swine
temperature gradients
trends
Temperature
sensors
Fiber optic sensors
gratings (spectra)
Ablation
Full width at half maximum

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Linearly chirped fiber Bragg grating response to thermal gradient: from bench tests to the real-time assessment during in vivo laser ablations of biological tissue. / Saccomandi, P.; Korganbayev, Sanzhar; Varalda , A. ; Gassino, R.; Tosi, Daniele; Massaroni, C. ; Caponero, M.A. ; Pop, R; Perrone, G; Diana, M; Vallan, A; Costamagna, G; Marescaux, J; Schena, E.

In: Journal of Biomedical Optics, Vol. 22, No. 9, 09.2017, p. 1-9.

Research output: Contribution to journalArticle

Saccomandi, P, Korganbayev, S, Varalda , A, Gassino, R, Tosi, D, Massaroni, C, Caponero, MA, Pop, R, Perrone, G, Diana, M, Vallan, A, Costamagna, G, Marescaux, J & Schena, E 2017, 'Linearly chirped fiber Bragg grating response to thermal gradient: from bench tests to the real-time assessment during in vivo laser ablations of biological tissue', Journal of Biomedical Optics, vol. 22, no. 9, pp. 1-9.
Saccomandi, P. ; Korganbayev, Sanzhar ; Varalda , A. ; Gassino, R. ; Tosi, Daniele ; Massaroni, C. ; Caponero, M.A. ; Pop, R ; Perrone, G ; Diana, M ; Vallan, A ; Costamagna, G ; Marescaux, J ; Schena, E. / Linearly chirped fiber Bragg grating response to thermal gradient: from bench tests to the real-time assessment during in vivo laser ablations of biological tissue. In: Journal of Biomedical Optics. 2017 ; Vol. 22, No. 9. pp. 1-9.
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AB - The response of a fiber optic sensor [linearly chirped fiber Bragg grating (LCFBG)] to a linear thermal gradient applied on its sensing length (i.e., 1.5 cm) has been investigated. After these bench tests, we assessed their feasibility for temperature monitoring during thermal tumor treatment. In particular, we performed experiments during ex vivo laser ablation (LA) in pig liver and in vivo thermal ablation in animal models (pigs). We investigated the following: (i) the relationship between the full width at half maximum of the LCFBG spectrum and the temperature difference among the extremities of the LCFBG and (ii) the relationship between the mean spectrum wavelength and the mean temperature acting on the LCFBG sensing area. These relationships showed a linear trend during both bench tests and LA in animal models. Thermal sensitivity was significant although different values were found with regards to bench tests and animal experiments. The linear trend and significant sensitivity allow hypothesizing a future use of this kind of sensor to monitor both temperature gradient and mean temperature within a tissue undergoing thermal treatment.

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