Liver autoreactivity in acute virus A, B and non-A, non-B hepatitis

S. Vento, B. M. McFarlane, C. G. McSorley, S. Ranieri, G. Giuliani-Piccari, P. R. Dal Monte, G. Verucchi, R. Williams, F. Chiodo, I. G. McFarlane

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Abstract

As part of an investigation into the question of whether virus-induced autoreactivity might contribute to liver damage in viral hepatitis, serial studies (from onset through recovery) of circulating liver autoantibodies have been performed in patients with uncomplicated acute virus A (AVH-A), B (AVH-B) and non-A, non-B (AVH-NANB) hepatitis in whom the time of onset of symptoms could be precisely documented. One hundred and forty-four sera from 35 patients were tested by radioimmunoassay for autoantibodies against the liver-derived lipoprotein complex, LSP, and also against one of its costituents - the asialoglycoprotein receptor, known as hepatic lectin (HL). Anti-LSP antibodies were found in all 10 patients with AVH-A in 17/18 with AVH-B and in 3/7 with AVH-NANB at titres that declined during recovery. Anti-HL antibodies were detected concurrently in 6 of the AVH-A patients and in 5 with AVH-B but on only 1 occasion in 1 patient with AVH-NANB. Transient cellular immunity to LSP, assayed by a T-lymphocyte migration inhibitory factor test, was detected in 4 of the 6 AVH-B patients tested, 2 of whom also showed concurrent reactivity to HL, but these cellular immune responses did not correlate with production of anti-LSP and/or anti-HL. The findings indicate that humoral immune responses to liver cell surface antigens are frequently triggered by hepatitis A and B viruses, possibly via induction of autoreactive, T-cell independent, liver antigen-specific B lymphocytes. These liver-specific autoreactions have the potential to contribute to hepatocellular damage in virus A and B hepatitis but it seems unlikely that autoimmunity plays a significant pathogenic role in NANB viral infections.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalJournal of Clinical and Laboratory Immunology
Volume25
Issue number1
Publication statusPublished - 1988
Externally publishedYes

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Cercopithecine Herpesvirus 1
Asialoglycoprotein Receptor
Hepatitis
Liver
Hepatitis A virus
Hepatitis B virus
Cellular Immunity
Autoantibodies
Viruses
T-Lymphocytes
Virus Diseases
Surface Antigens
Humoral Immunity
Autoimmunity
Lipoproteins
Radioimmunoassay
Anti-Idiotypic Antibodies
B-Lymphocytes
Antigens
Antibodies

ASJC Scopus subject areas

  • Immunology

Cite this

Vento, S., McFarlane, B. M., McSorley, C. G., Ranieri, S., Giuliani-Piccari, G., Dal Monte, P. R., ... McFarlane, I. G. (1988). Liver autoreactivity in acute virus A, B and non-A, non-B hepatitis. Journal of Clinical and Laboratory Immunology, 25(1), 1-7.

Liver autoreactivity in acute virus A, B and non-A, non-B hepatitis. / Vento, S.; McFarlane, B. M.; McSorley, C. G.; Ranieri, S.; Giuliani-Piccari, G.; Dal Monte, P. R.; Verucchi, G.; Williams, R.; Chiodo, F.; McFarlane, I. G.

In: Journal of Clinical and Laboratory Immunology, Vol. 25, No. 1, 1988, p. 1-7.

Research output: Contribution to journalArticle

Vento, S, McFarlane, BM, McSorley, CG, Ranieri, S, Giuliani-Piccari, G, Dal Monte, PR, Verucchi, G, Williams, R, Chiodo, F & McFarlane, IG 1988, 'Liver autoreactivity in acute virus A, B and non-A, non-B hepatitis', Journal of Clinical and Laboratory Immunology, vol. 25, no. 1, pp. 1-7.
Vento S, McFarlane BM, McSorley CG, Ranieri S, Giuliani-Piccari G, Dal Monte PR et al. Liver autoreactivity in acute virus A, B and non-A, non-B hepatitis. Journal of Clinical and Laboratory Immunology. 1988;25(1):1-7.
Vento, S. ; McFarlane, B. M. ; McSorley, C. G. ; Ranieri, S. ; Giuliani-Piccari, G. ; Dal Monte, P. R. ; Verucchi, G. ; Williams, R. ; Chiodo, F. ; McFarlane, I. G. / Liver autoreactivity in acute virus A, B and non-A, non-B hepatitis. In: Journal of Clinical and Laboratory Immunology. 1988 ; Vol. 25, No. 1. pp. 1-7.
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