Long-range and short-range tumor-stroma networks synergistically contribute to tumor-associated epilepsy

Xiao Yuan Mao, Tursonjan Tokay, Hong Hao Zhou, Wei Lin Jin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Epileptic seizures are frequently caused by brain tumors. Traditional anti-epileptic treatments do not acquire satisfactory responses. Preoperative and postoperative seizures seriously influence the quality of life of patients. Thus, tumor-associated epilepsy (TAE) is an important subject of the current research. The delineation of the etiology of epileptogenesis in patients with primary brain tumor may help to find the novel and effective drug targets for treating this disease. In this review, we describe the current status of treatment of TAE. More importantly, we focus on the factors that are involved in the functional connectivity between tumors and stromal cells. We propose that there exist two modes, namely, long-range and short-range modes, which likely trigger neuronal hyperexcitation and subsequent epileptic seizures. The long-range mode is referred to as factors released by tumors including glutamate and GABA, binding to the corresponding receptor on the cellular membrane and causing neuronal hyperactivity, while the short-range mode is considered to involve direct intracellular communication between tumor cells and stromas. Gap junctions and tunneling nanotube network are involved in cellular interconnections. Future investigations focused on those two modes may find a potential novel therapeutic target for treating TAE.

Original languageEnglish
Pages (from-to)33451-33460
Number of pages10
JournalOncotarget
Volume7
Issue number22
DOIs
Publication statusPublished - May 31 2016

Fingerprint

Epilepsy
Neoplasms
Brain Neoplasms
Nanotubes
Gap Junctions
Stromal Cells
gamma-Aminobutyric Acid
Glutamic Acid
Seizures
Therapeutics
Communication
Quality of Life
Membranes
Research
Pharmaceutical Preparations

Keywords

  • Brain tumor
  • Long-range mode
  • Short-range mode
  • Tumor microenvironment
  • Tumor-associated epilepsy

ASJC Scopus subject areas

  • Oncology

Cite this

Long-range and short-range tumor-stroma networks synergistically contribute to tumor-associated epilepsy. / Mao, Xiao Yuan; Tokay, Tursonjan; Zhou, Hong Hao; Jin, Wei Lin.

In: Oncotarget, Vol. 7, No. 22, 31.05.2016, p. 33451-33460.

Research output: Contribution to journalArticle

Mao, Xiao Yuan ; Tokay, Tursonjan ; Zhou, Hong Hao ; Jin, Wei Lin. / Long-range and short-range tumor-stroma networks synergistically contribute to tumor-associated epilepsy. In: Oncotarget. 2016 ; Vol. 7, No. 22. pp. 33451-33460.
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