Loss of cell-cell and cell-matrix adhesion molecules in colorectal cancer

A. K. Nigam, F. J. Savage, P. B. Boulos, G. W H Stamp, D. Liu, M. Pignatelli

Research output: Contribution to journalArticle

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Abstract

Adhesion molecules are thought to play a vital role in the induction and maintenance of tissue differentiation and their loss or down-regulation has been implicated in the neoplastic process. Recent studies have shown that the morphoregulatory activites are a consequence of interactive processes between several cell adhesion molecules rather than the function of a single molecule. Therefore, we have investigated a panel of adhesion molecules including members of the integrin, cadherin and immunoglobin superfamily in colorectal cancer. Twenty-eight consecutive colorectal adenocarcinomas were stained using an avidin-biotin indirect immunoperoxidase technique. Our results showed a consistent loss of the α2 and β1 integrin subunits ( 21 28 = 75% and 22 28 = 78.6% respectively) and a decrease in expression of E-cadherin in 5 5 poorly differentiated adenocarcinomas. Carcinoembryonic antigen expression was preserved but with basolateral accentuation seen in tumours. There was no statistical correlation with Dukes' stage. These results provide further evidence that in colorectal cancer there is a widespread deregulated expression of cell-cell and cell-matrix adhesion molecules. Changes in the expression and function of adhesion molecules which regulate growth and differentiation may play a role in the behaviour of colorectal cancer.

Original languageEnglish
Pages (from-to)507-514
Number of pages8
JournalBritish Journal of Cancer
Volume68
Issue number3
Publication statusPublished - Sep 1993
Externally publishedYes

Fingerprint

Cell-Matrix Junctions
Cell Adhesion Molecules
Colorectal Neoplasms
Cadherins
Integrins
Adenocarcinoma
Neoplastic Processes
Avidin
Carcinoembryonic Antigen
Biotin
Immunoenzyme Techniques
Down-Regulation
Maintenance
Growth
Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Nigam, A. K., Savage, F. J., Boulos, P. B., Stamp, G. W. H., Liu, D., & Pignatelli, M. (1993). Loss of cell-cell and cell-matrix adhesion molecules in colorectal cancer. British Journal of Cancer, 68(3), 507-514.

Loss of cell-cell and cell-matrix adhesion molecules in colorectal cancer. / Nigam, A. K.; Savage, F. J.; Boulos, P. B.; Stamp, G. W H; Liu, D.; Pignatelli, M.

In: British Journal of Cancer, Vol. 68, No. 3, 09.1993, p. 507-514.

Research output: Contribution to journalArticle

Nigam, AK, Savage, FJ, Boulos, PB, Stamp, GWH, Liu, D & Pignatelli, M 1993, 'Loss of cell-cell and cell-matrix adhesion molecules in colorectal cancer', British Journal of Cancer, vol. 68, no. 3, pp. 507-514.
Nigam AK, Savage FJ, Boulos PB, Stamp GWH, Liu D, Pignatelli M. Loss of cell-cell and cell-matrix adhesion molecules in colorectal cancer. British Journal of Cancer. 1993 Sep;68(3):507-514.
Nigam, A. K. ; Savage, F. J. ; Boulos, P. B. ; Stamp, G. W H ; Liu, D. ; Pignatelli, M. / Loss of cell-cell and cell-matrix adhesion molecules in colorectal cancer. In: British Journal of Cancer. 1993 ; Vol. 68, No. 3. pp. 507-514.
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