Low expression of β1, α2 and α3 subunits of VLA integrins in malignant mammary tumours

M. Pignatelli, A. M. Hanby, G. W H Stamp

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

The Very Late Antigens (VLAs) are αβ heterodimeric transmembrane proteins mediating cell-substratum as well as cell-cell interactions. Changes in their expression and/or function seem to occur in a number of invasive carcinomas and may at least in part explain their abnormal patterns of growth and differentiation. Using monoclonal antibodies to the β1 (DH12, A1A-5), α2 (B1.515) and α3 (E1.56) chains, VLA-2 (α2β1) and VLA-3 (α3β1) were studied on cryostat sections of three fibroadenomas and 43 invasive breast carcinomas (29 ductal, 14 lobular) by the avidin-biotin complex immunoperioxidase technique. In non-neoplastic breast tissue and in fibroadenomas VLA-2 and VLA-3 were expressed by myoepithelial cells and on the basolateral surface of the luminal cells. There was weak or absent expression of α2, α3 and the common β1 chain in the majority of invasive carcinomas compared to the adjacent normal breast epithelium and preinvasive (in-situ) carcinomas. In addition, the expression of the α2 chain of VLA-2 was reduced significantly (P

Original languageEnglish
Pages (from-to)25-32
Number of pages8
JournalJournal of Pathology
Volume165
Issue number1
DOIs
Publication statusPublished - 1991
Externally publishedYes

Fingerprint

Integrin alpha2beta1
Integrins
Breast Neoplasms
Fibroadenoma
Antigens
Breast
Carcinoma, Ductal, Breast
Carcinoma
Avidin
Carcinoma in Situ
Biotin
Cell Communication
Epithelium
Monoclonal Antibodies
Growth
Proteins

Keywords

  • breast carcinoma
  • extracellular matrix
  • immunohistochemistry
  • integrin
  • VLA

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Low expression of β1, α2 and α3 subunits of VLA integrins in malignant mammary tumours. / Pignatelli, M.; Hanby, A. M.; Stamp, G. W H.

In: Journal of Pathology, Vol. 165, No. 1, 1991, p. 25-32.

Research output: Contribution to journalArticle

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