Macrolide antibiotics: Characteristic features of interaction with organoids, intracellular distribution and sulfalen effect on it

A. E. Gulyaev, G. Kivman Ya.

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Abstract

Interaction of erythromycin and oleandomycin with isolated subcellular fractions of rat liver homogenates and intracellular distribution of the antibiotics were studied. It was found that the macrolides were bound by the cell organoids. The binding was partially reversible. The intracellular distribution was characterized by accumulation of erythromycin and oleandomycin in the mitochondrial fraction while erythromycin preserved higher activity in cytosol as compared to oleandomycin. Sulfalen induced redistribution of the macrolides. It decreased absorption of the macrolides by the organoids and increased the concentration of free erythromycin and especially oleandomycin in cytosol.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalAntibiotiki i Medicinskaya Biotechnologiya
Volume30
Issue number2
Publication statusPublished - Jan 1 1985

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ASJC Scopus subject areas

  • Medicine(all)

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