Macrolide antibiotics

Characteristic features of interaction with organoids, intracellular distribution and sulfalen effect on it

A. E. Gulyaev, G. Kivman Ya.

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Interaction of erythromycin and oleandomycin with isolated subcellular fractions of rat liver homogenates and intracellular distribution of the antibiotics were studied. It was found that the macrolides were bound by the cell organoids. The binding was partially reversible. The intracellular distribution was characterized by accumulation of erythromycin and oleandomycin in the mitochondrial fraction while erythromycin preserved higher activity in cytosol as compared to oleandomycin. Sulfalen induced redistribution of the macrolides. It decreased absorption of the macrolides by the organoids and increased the concentration of free erythromycin and especially oleandomycin in cytosol.

Original languageEnglish
Title of host publicationAntibiotiki i Medicinskaya Biotechnologiya
Pages103-106
Number of pages4
Volume30
Edition2
Publication statusPublished - 1985
Externally publishedYes

Fingerprint

Oleandomycin
Organoids
Macrolides
Erythromycin
Anti-Bacterial Agents
Cytosol
Subcellular Fractions
Liver

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gulyaev, A. E., & Kivman Ya., G. (1985). Macrolide antibiotics: Characteristic features of interaction with organoids, intracellular distribution and sulfalen effect on it. In Antibiotiki i Medicinskaya Biotechnologiya (2 ed., Vol. 30, pp. 103-106)

Macrolide antibiotics : Characteristic features of interaction with organoids, intracellular distribution and sulfalen effect on it. / Gulyaev, A. E.; Kivman Ya., G.

Antibiotiki i Medicinskaya Biotechnologiya. Vol. 30 2. ed. 1985. p. 103-106.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gulyaev, AE & Kivman Ya., G 1985, Macrolide antibiotics: Characteristic features of interaction with organoids, intracellular distribution and sulfalen effect on it. in Antibiotiki i Medicinskaya Biotechnologiya. 2 edn, vol. 30, pp. 103-106.
Gulyaev AE, Kivman Ya. G. Macrolide antibiotics: Characteristic features of interaction with organoids, intracellular distribution and sulfalen effect on it. In Antibiotiki i Medicinskaya Biotechnologiya. 2 ed. Vol. 30. 1985. p. 103-106
Gulyaev, A. E. ; Kivman Ya., G. / Macrolide antibiotics : Characteristic features of interaction with organoids, intracellular distribution and sulfalen effect on it. Antibiotiki i Medicinskaya Biotechnologiya. Vol. 30 2. ed. 1985. pp. 103-106
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