Abstract
Composite monolithic adsorbents were prepared by the incorporation of neutral polystyrene divinylbenzene (PS-DVB) microparticles into macroporous polymer structures produced by cryogelation of agarose or poly(vinyl alcohol). The composite materials exhibited excellent flow-through properties. Scanning electron microscopy of the composite cryogels revealed that the microparticles were covered by thin films of poly(vinyl alcohol) or agarose and thus were withheld in the monolith structure. Plain PS-DVB microparticles showed efficient adsorption of albumin-bound toxins related to liver failure (bilirubin and cholic acid) and of cytokines (tumor necrosis factor-alpha and interleukin-6). The rates of adsorption and the amount of adsorbed factors were lower for the embedded microparticles as compared to the parent PS-DVB microparticles, indicating the importance of the accessibility of the adsorbent pores. Still, the macroporous composite materials showed efficient adsorption of albumin-bound toxins related to liver failure as well as efficient binding of cytokines, combined with good blood compatibility. Thus, the incorporation of microparticles into macroporous polymer structures may provide an option for the development of adsorption modules for extracorporeal blood purification.
| Original language | English |
|---|---|
| Article number | 348412 |
| Journal | Journal of Chemistry |
| DOIs | |
| Publication status | Published - 2013 |
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ASJC Scopus subject areas
- Chemistry(all)
Cite this
Macroporous composite cryogels with embedded polystyrene divinylbenzene microparticles for the adsorption of toxic metabolites from blood. / Eichhorn, Tanja; Ivanov, Alexander E.; Dainiak, Maria B.; Leistner, André; Linsberger, Ingrid; Jungvid, Hans; Mikhalovsky, Sergey V.; Weber, Viktoria.
In: Journal of Chemistry, 2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Macroporous composite cryogels with embedded polystyrene divinylbenzene microparticles for the adsorption of toxic metabolites from blood
AU - Eichhorn, Tanja
AU - Ivanov, Alexander E.
AU - Dainiak, Maria B.
AU - Leistner, André
AU - Linsberger, Ingrid
AU - Jungvid, Hans
AU - Mikhalovsky, Sergey V.
AU - Weber, Viktoria
PY - 2013
Y1 - 2013
N2 - Composite monolithic adsorbents were prepared by the incorporation of neutral polystyrene divinylbenzene (PS-DVB) microparticles into macroporous polymer structures produced by cryogelation of agarose or poly(vinyl alcohol). The composite materials exhibited excellent flow-through properties. Scanning electron microscopy of the composite cryogels revealed that the microparticles were covered by thin films of poly(vinyl alcohol) or agarose and thus were withheld in the monolith structure. Plain PS-DVB microparticles showed efficient adsorption of albumin-bound toxins related to liver failure (bilirubin and cholic acid) and of cytokines (tumor necrosis factor-alpha and interleukin-6). The rates of adsorption and the amount of adsorbed factors were lower for the embedded microparticles as compared to the parent PS-DVB microparticles, indicating the importance of the accessibility of the adsorbent pores. Still, the macroporous composite materials showed efficient adsorption of albumin-bound toxins related to liver failure as well as efficient binding of cytokines, combined with good blood compatibility. Thus, the incorporation of microparticles into macroporous polymer structures may provide an option for the development of adsorption modules for extracorporeal blood purification.
AB - Composite monolithic adsorbents were prepared by the incorporation of neutral polystyrene divinylbenzene (PS-DVB) microparticles into macroporous polymer structures produced by cryogelation of agarose or poly(vinyl alcohol). The composite materials exhibited excellent flow-through properties. Scanning electron microscopy of the composite cryogels revealed that the microparticles were covered by thin films of poly(vinyl alcohol) or agarose and thus were withheld in the monolith structure. Plain PS-DVB microparticles showed efficient adsorption of albumin-bound toxins related to liver failure (bilirubin and cholic acid) and of cytokines (tumor necrosis factor-alpha and interleukin-6). The rates of adsorption and the amount of adsorbed factors were lower for the embedded microparticles as compared to the parent PS-DVB microparticles, indicating the importance of the accessibility of the adsorbent pores. Still, the macroporous composite materials showed efficient adsorption of albumin-bound toxins related to liver failure as well as efficient binding of cytokines, combined with good blood compatibility. Thus, the incorporation of microparticles into macroporous polymer structures may provide an option for the development of adsorption modules for extracorporeal blood purification.
UR - http://www.scopus.com/inward/record.url?scp=84877937987&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84877937987&partnerID=8YFLogxK
U2 - 10.1155/2013/348412
DO - 10.1155/2013/348412
M3 - Article
AN - SCOPUS:84877937987
JO - E-Journal of Chemistry
JF - E-Journal of Chemistry
SN - 2090-9063
M1 - 348412
ER -