Macroporous composite cryogels with embedded polystyrene divinylbenzene microparticles for the adsorption of toxic metabolites from blood

Tanja Eichhorn, Alexander E. Ivanov, Maria B. Dainiak, André Leistner, Ingrid Linsberger, Hans Jungvid, Sergey V. Mikhalovsky, Viktoria Weber

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Composite monolithic adsorbents were prepared by the incorporation of neutral polystyrene divinylbenzene (PS-DVB) microparticles into macroporous polymer structures produced by cryogelation of agarose or poly(vinyl alcohol). The composite materials exhibited excellent flow-through properties. Scanning electron microscopy of the composite cryogels revealed that the microparticles were covered by thin films of poly(vinyl alcohol) or agarose and thus were withheld in the monolith structure. Plain PS-DVB microparticles showed efficient adsorption of albumin-bound toxins related to liver failure (bilirubin and cholic acid) and of cytokines (tumor necrosis factor-alpha and interleukin-6). The rates of adsorption and the amount of adsorbed factors were lower for the embedded microparticles as compared to the parent PS-DVB microparticles, indicating the importance of the accessibility of the adsorbent pores. Still, the macroporous composite materials showed efficient adsorption of albumin-bound toxins related to liver failure as well as efficient binding of cytokines, combined with good blood compatibility. Thus, the incorporation of microparticles into macroporous polymer structures may provide an option for the development of adsorption modules for extracorporeal blood purification.

Original languageEnglish
Article number348412
JournalJournal of Chemistry
DOIs
Publication statusPublished - 2013

Fingerprint

divinyl benzene
Cryogels
Poisons
Polystyrenes
Metabolites
Blood
Adsorption
Composite materials
Liver
Sepharose
Adsorbents
Albumins
Polymers
Alcohols
Cytokines
Cholic Acid
Bilirubin
Purification
Interleukin-6
Tumor Necrosis Factor-alpha

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Macroporous composite cryogels with embedded polystyrene divinylbenzene microparticles for the adsorption of toxic metabolites from blood. / Eichhorn, Tanja; Ivanov, Alexander E.; Dainiak, Maria B.; Leistner, André; Linsberger, Ingrid; Jungvid, Hans; Mikhalovsky, Sergey V.; Weber, Viktoria.

In: Journal of Chemistry, 2013.

Research output: Contribution to journalArticle

Eichhorn, Tanja ; Ivanov, Alexander E. ; Dainiak, Maria B. ; Leistner, André ; Linsberger, Ingrid ; Jungvid, Hans ; Mikhalovsky, Sergey V. ; Weber, Viktoria. / Macroporous composite cryogels with embedded polystyrene divinylbenzene microparticles for the adsorption of toxic metabolites from blood. In: Journal of Chemistry. 2013.
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AU - Jungvid, Hans

AU - Mikhalovsky, Sergey V.

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