Abstract
The function of Maid (GCIP), a cyclinD-binding helix-loop-helix protein, was analyzed by targeted disruption in mice. We show that Maid function is not required for normal embryonic development. However, older Maid-deficient mice - in contrast to wild-type controls - develop hepatocellular carcinomas. Therefore, we studied the role of Maid during cell cycle progression after partial hepatectomy (PH). Lack of Maid expression after PH was associated with a delay in G1/S-phase progression as evidenced by delayed cyclinA expression and DNA replication in Maid-deficient mice. However, at later time points liver mass was restored normally. Conclusion: These results indicate that Maid is involved in G1/S-phase progression of hepatocytes, which in older animals is associated with the development of liver tumors.
| Original language | English |
|---|---|
| Pages (from-to) | 404-411 |
| Number of pages | 8 |
| Journal | Hepatology |
| Volume | 45 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2007 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Hepatology
Cite this
Maid (GCIP) is involved in cell cycle control of hepatocytes. / Sonnenberg-Riethmacher, Eva; Wüstefeld, Torsten; Miehe, Michaela; Trautwein, Christian; Riethmacher, Dieter.
In: Hepatology, Vol. 45, No. 2, 02.2007, p. 404-411.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Maid (GCIP) is involved in cell cycle control of hepatocytes
AU - Sonnenberg-Riethmacher, Eva
AU - Wüstefeld, Torsten
AU - Miehe, Michaela
AU - Trautwein, Christian
AU - Riethmacher, Dieter
PY - 2007/2
Y1 - 2007/2
N2 - The function of Maid (GCIP), a cyclinD-binding helix-loop-helix protein, was analyzed by targeted disruption in mice. We show that Maid function is not required for normal embryonic development. However, older Maid-deficient mice - in contrast to wild-type controls - develop hepatocellular carcinomas. Therefore, we studied the role of Maid during cell cycle progression after partial hepatectomy (PH). Lack of Maid expression after PH was associated with a delay in G1/S-phase progression as evidenced by delayed cyclinA expression and DNA replication in Maid-deficient mice. However, at later time points liver mass was restored normally. Conclusion: These results indicate that Maid is involved in G1/S-phase progression of hepatocytes, which in older animals is associated with the development of liver tumors.
AB - The function of Maid (GCIP), a cyclinD-binding helix-loop-helix protein, was analyzed by targeted disruption in mice. We show that Maid function is not required for normal embryonic development. However, older Maid-deficient mice - in contrast to wild-type controls - develop hepatocellular carcinomas. Therefore, we studied the role of Maid during cell cycle progression after partial hepatectomy (PH). Lack of Maid expression after PH was associated with a delay in G1/S-phase progression as evidenced by delayed cyclinA expression and DNA replication in Maid-deficient mice. However, at later time points liver mass was restored normally. Conclusion: These results indicate that Maid is involved in G1/S-phase progression of hepatocytes, which in older animals is associated with the development of liver tumors.
UR - http://www.scopus.com/inward/record.url?scp=33847731162&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847731162&partnerID=8YFLogxK
U2 - 10.1002/hep.21461
DO - 10.1002/hep.21461
M3 - Article
VL - 45
SP - 404
EP - 411
JO - Hepatology
JF - Hepatology
SN - 0270-9139
IS - 2
ER -