Maid (GCIP) is involved in cell cycle control of hepatocytes

Eva Sonnenberg-Riethmacher, Torsten Wüstefeld, Michaela Miehe, Christian Trautwein, Dieter Riethmacher

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The function of Maid (GCIP), a cyclinD-binding helix-loop-helix protein, was analyzed by targeted disruption in mice. We show that Maid function is not required for normal embryonic development. However, older Maid-deficient mice - in contrast to wild-type controls - develop hepatocellular carcinomas. Therefore, we studied the role of Maid during cell cycle progression after partial hepatectomy (PH). Lack of Maid expression after PH was associated with a delay in G1/S-phase progression as evidenced by delayed cyclinA expression and DNA replication in Maid-deficient mice. However, at later time points liver mass was restored normally. Conclusion: These results indicate that Maid is involved in G1/S-phase progression of hepatocytes, which in older animals is associated with the development of liver tumors.

Original languageEnglish
Pages (from-to)404-411
Number of pages8
JournalHepatology
Volume45
Issue number2
DOIs
Publication statusPublished - Feb 2007
Externally publishedYes

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Cell Cycle Checkpoints
Hepatocytes
G1 Phase
Hepatectomy
S Phase
Liver
DNA Replication
Embryonic Development
Hepatocellular Carcinoma
Cell Cycle
Neoplasms
Proteins

ASJC Scopus subject areas

  • Hepatology

Cite this

Maid (GCIP) is involved in cell cycle control of hepatocytes. / Sonnenberg-Riethmacher, Eva; Wüstefeld, Torsten; Miehe, Michaela; Trautwein, Christian; Riethmacher, Dieter.

In: Hepatology, Vol. 45, No. 2, 02.2007, p. 404-411.

Research output: Contribution to journalArticle

Sonnenberg-Riethmacher, Eva ; Wüstefeld, Torsten ; Miehe, Michaela ; Trautwein, Christian ; Riethmacher, Dieter. / Maid (GCIP) is involved in cell cycle control of hepatocytes. In: Hepatology. 2007 ; Vol. 45, No. 2. pp. 404-411.
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