Maid (GCIP) is involved in cell cycle control of hepatocytes

Eva Sonnenberg-Riethmacher, Torsten Wüstefeld, Michaela Miehe, Christian Trautwein, Dieter Riethmacher

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The function of Maid (GCIP), a cyclinD-binding helix-loop-helix protein, was analyzed by targeted disruption in mice. We show that Maid function is not required for normal embryonic development. However, older Maid-deficient mice - in contrast to wild-type controls - develop hepatocellular carcinomas. Therefore, we studied the role of Maid during cell cycle progression after partial hepatectomy (PH). Lack of Maid expression after PH was associated with a delay in G1/S-phase progression as evidenced by delayed cyclinA expression and DNA replication in Maid-deficient mice. However, at later time points liver mass was restored normally. Conclusion: These results indicate that Maid is involved in G1/S-phase progression of hepatocytes, which in older animals is associated with the development of liver tumors.

Original languageEnglish
Pages (from-to)404-411
Number of pages8
JournalHepatology
Volume45
Issue number2
DOIs
Publication statusPublished - Feb 1 2007

ASJC Scopus subject areas

  • Hepatology

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