TY - JOUR
T1 - Maid (GCIP) is involved in cell cycle control of hepatocytes
AU - Sonnenberg-Riethmacher, Eva
AU - Wüstefeld, Torsten
AU - Miehe, Michaela
AU - Trautwein, Christian
AU - Riethmacher, Dieter
PY - 2007/2
Y1 - 2007/2
N2 - The function of Maid (GCIP), a cyclinD-binding helix-loop-helix protein, was analyzed by targeted disruption in mice. We show that Maid function is not required for normal embryonic development. However, older Maid-deficient mice - in contrast to wild-type controls - develop hepatocellular carcinomas. Therefore, we studied the role of Maid during cell cycle progression after partial hepatectomy (PH). Lack of Maid expression after PH was associated with a delay in G1/S-phase progression as evidenced by delayed cyclinA expression and DNA replication in Maid-deficient mice. However, at later time points liver mass was restored normally. Conclusion: These results indicate that Maid is involved in G1/S-phase progression of hepatocytes, which in older animals is associated with the development of liver tumors.
AB - The function of Maid (GCIP), a cyclinD-binding helix-loop-helix protein, was analyzed by targeted disruption in mice. We show that Maid function is not required for normal embryonic development. However, older Maid-deficient mice - in contrast to wild-type controls - develop hepatocellular carcinomas. Therefore, we studied the role of Maid during cell cycle progression after partial hepatectomy (PH). Lack of Maid expression after PH was associated with a delay in G1/S-phase progression as evidenced by delayed cyclinA expression and DNA replication in Maid-deficient mice. However, at later time points liver mass was restored normally. Conclusion: These results indicate that Maid is involved in G1/S-phase progression of hepatocytes, which in older animals is associated with the development of liver tumors.
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U2 - 10.1002/hep.21461
DO - 10.1002/hep.21461
M3 - Article
C2 - 17256742
AN - SCOPUS:33847731162
VL - 45
SP - 404
EP - 411
JO - Hepatology
JF - Hepatology
SN - 0270-9139
IS - 2
ER -