Mammalian chromodomain proteins: their role in genome organisation and expression

D O Jones; I G Cowell; P B Singh

doi:10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E

Mammalian chromodomain proteins: their role in genome organisation and expression

D O Jones, I G Cowell, P B Singh

Department of Medicine

Research output: Contribution to journal › Review article › peer-review

231 Citations (Scopus)

Abstract

The chromodomain is a highly conserved sequence motif that has been identified in a variety of animal and plant species. In mammals, chromodomain proteins appear to be either structural components of large macromolecular chromatin complexes or proteins involved in remodelling chromatin structure. Recent work has suggested that apart from a role in regulating gene activity, chromodomain proteins may also play roles in genome organisation. This article reviews progress made in characterising mammalian chromodomain proteins and emphasises their emerging role in the regulation of gene expression and genome organisation. BioEssays 22:124-137, 2000.

Original language	English
Pages (from-to)	124-37
Number of pages	14
Journal	BioEssays
Volume	22
Issue number	2
DOIs	https://doi.org/10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E
Publication status	Published - Feb 2000

Keywords

Amino Acid Sequence
Animals
Chromatin
Chromosomal Proteins, Non-Histone
Gene Expression
Genome
Humans
Mice
Models, Molecular
Molecular Sequence Data
Polycomb-Group Proteins
Protein Conformation
Repressor Proteins
Sequence Homology, Amino Acid
Journal Article
Review

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10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E

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title = "Mammalian chromodomain proteins: their role in genome organisation and expression",

abstract = "The chromodomain is a highly conserved sequence motif that has been identified in a variety of animal and plant species. In mammals, chromodomain proteins appear to be either structural components of large macromolecular chromatin complexes or proteins involved in remodelling chromatin structure. Recent work has suggested that apart from a role in regulating gene activity, chromodomain proteins may also play roles in genome organisation. This article reviews progress made in characterising mammalian chromodomain proteins and emphasises their emerging role in the regulation of gene expression and genome organisation. BioEssays 22:124-137, 2000.",

keywords = "Amino Acid Sequence, Animals, Chromatin, Chromosomal Proteins, Non-Histone, Gene Expression, Genome, Humans, Mice, Models, Molecular, Molecular Sequence Data, Polycomb-Group Proteins, Protein Conformation, Repressor Proteins, Sequence Homology, Amino Acid, Journal Article, Review",

author = "Jones, {D O} and Cowell, {I G} and Singh, {P B}",

year = "2000",

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TY - JOUR

T1 - Mammalian chromodomain proteins

T2 - their role in genome organisation and expression

AU - Jones, D O

AU - Cowell, I G

AU - Singh, P B

PY - 2000/2

Y1 - 2000/2

N2 - The chromodomain is a highly conserved sequence motif that has been identified in a variety of animal and plant species. In mammals, chromodomain proteins appear to be either structural components of large macromolecular chromatin complexes or proteins involved in remodelling chromatin structure. Recent work has suggested that apart from a role in regulating gene activity, chromodomain proteins may also play roles in genome organisation. This article reviews progress made in characterising mammalian chromodomain proteins and emphasises their emerging role in the regulation of gene expression and genome organisation. BioEssays 22:124-137, 2000.

AB - The chromodomain is a highly conserved sequence motif that has been identified in a variety of animal and plant species. In mammals, chromodomain proteins appear to be either structural components of large macromolecular chromatin complexes or proteins involved in remodelling chromatin structure. Recent work has suggested that apart from a role in regulating gene activity, chromodomain proteins may also play roles in genome organisation. This article reviews progress made in characterising mammalian chromodomain proteins and emphasises their emerging role in the regulation of gene expression and genome organisation. BioEssays 22:124-137, 2000.

KW - Amino Acid Sequence

KW - Animals

KW - Chromatin

KW - Chromosomal Proteins, Non-Histone

KW - Gene Expression

KW - Genome

KW - Humans

KW - Mice

KW - Models, Molecular

KW - Molecular Sequence Data

KW - Polycomb-Group Proteins

KW - Protein Conformation

KW - Repressor Proteins

KW - Sequence Homology, Amino Acid

KW - Journal Article

KW - Review

U2 - 10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E

DO - 10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E

M3 - Review article

C2 - 10655032

SN - 0265-9247

VL - 22

SP - 124

EP - 137

JO - BioEssays

JF - BioEssays

IS - 2

ER -

Mammalian chromodomain proteins: their role in genome organisation and expression

Abstract

Keywords

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