Mammalian chromodomain proteins: their role in genome organisation and expression

D O Jones, I G Cowell, P B Singh

Research output: Contribution to journalReview articlepeer-review

210 Citations (Scopus)


The chromodomain is a highly conserved sequence motif that has been identified in a variety of animal and plant species. In mammals, chromodomain proteins appear to be either structural components of large macromolecular chromatin complexes or proteins involved in remodelling chromatin structure. Recent work has suggested that apart from a role in regulating gene activity, chromodomain proteins may also play roles in genome organisation. This article reviews progress made in characterising mammalian chromodomain proteins and emphasises their emerging role in the regulation of gene expression and genome organisation. BioEssays 22:124-137, 2000.

Original languageEnglish
Pages (from-to)124-37
Number of pages14
Issue number2
Publication statusPublished - Feb 2000


  • Amino Acid Sequence
  • Animals
  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • Gene Expression
  • Genome
  • Humans
  • Mice
  • Models, Molecular
  • Molecular Sequence Data
  • Polycomb-Group Proteins
  • Protein Conformation
  • Repressor Proteins
  • Sequence Homology, Amino Acid
  • Journal Article
  • Review

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