Mammalian chromodomain proteins

their role in genome organisation and expression

D O Jones, I G Cowell, P B Singh

Research output: Contribution to journalReview article

201 Citations (Scopus)

Abstract

The chromodomain is a highly conserved sequence motif that has been identified in a variety of animal and plant species. In mammals, chromodomain proteins appear to be either structural components of large macromolecular chromatin complexes or proteins involved in remodelling chromatin structure. Recent work has suggested that apart from a role in regulating gene activity, chromodomain proteins may also play roles in genome organisation. This article reviews progress made in characterising mammalian chromodomain proteins and emphasises their emerging role in the regulation of gene expression and genome organisation. BioEssays 22:124-137, 2000.

Original languageEnglish
Pages (from-to)124-37
Number of pages14
JournalBioEssays
Volume22
Issue number2
DOIs
Publication statusPublished - Feb 2000

Fingerprint

Genes
Genome
Chromatin
Proteins
Macromolecular Substances
Mammals
Chromatin Assembly and Disassembly
Conserved Sequence
Gene Expression Regulation
Gene expression
Animals

Keywords

  • Amino Acid Sequence
  • Animals
  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • Gene Expression
  • Genome
  • Humans
  • Mice
  • Models, Molecular
  • Molecular Sequence Data
  • Polycomb-Group Proteins
  • Protein Conformation
  • Repressor Proteins
  • Sequence Homology, Amino Acid
  • Journal Article
  • Review

Cite this

Mammalian chromodomain proteins : their role in genome organisation and expression. / Jones, D O; Cowell, I G; Singh, P B.

In: BioEssays, Vol. 22, No. 2, 02.2000, p. 124-37.

Research output: Contribution to journalReview article

Jones, D O ; Cowell, I G ; Singh, P B. / Mammalian chromodomain proteins : their role in genome organisation and expression. In: BioEssays. 2000 ; Vol. 22, No. 2. pp. 124-37.
@article{be14ba3507d94f9283773d49f087f757,
title = "Mammalian chromodomain proteins: their role in genome organisation and expression",
abstract = "The chromodomain is a highly conserved sequence motif that has been identified in a variety of animal and plant species. In mammals, chromodomain proteins appear to be either structural components of large macromolecular chromatin complexes or proteins involved in remodelling chromatin structure. Recent work has suggested that apart from a role in regulating gene activity, chromodomain proteins may also play roles in genome organisation. This article reviews progress made in characterising mammalian chromodomain proteins and emphasises their emerging role in the regulation of gene expression and genome organisation. BioEssays 22:124-137, 2000.",
keywords = "Amino Acid Sequence, Animals, Chromatin, Chromosomal Proteins, Non-Histone, Gene Expression, Genome, Humans, Mice, Models, Molecular, Molecular Sequence Data, Polycomb-Group Proteins, Protein Conformation, Repressor Proteins, Sequence Homology, Amino Acid, Journal Article, Review",
author = "Jones, {D O} and Cowell, {I G} and Singh, {P B}",
note = "Copyright 2000 John Wiley & Sons, Inc.",
year = "2000",
month = "2",
doi = "10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E",
language = "English",
volume = "22",
pages = "124--37",
journal = "BioEssays",
issn = "0265-9247",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Mammalian chromodomain proteins

T2 - their role in genome organisation and expression

AU - Jones, D O

AU - Cowell, I G

AU - Singh, P B

N1 - Copyright 2000 John Wiley & Sons, Inc.

PY - 2000/2

Y1 - 2000/2

N2 - The chromodomain is a highly conserved sequence motif that has been identified in a variety of animal and plant species. In mammals, chromodomain proteins appear to be either structural components of large macromolecular chromatin complexes or proteins involved in remodelling chromatin structure. Recent work has suggested that apart from a role in regulating gene activity, chromodomain proteins may also play roles in genome organisation. This article reviews progress made in characterising mammalian chromodomain proteins and emphasises their emerging role in the regulation of gene expression and genome organisation. BioEssays 22:124-137, 2000.

AB - The chromodomain is a highly conserved sequence motif that has been identified in a variety of animal and plant species. In mammals, chromodomain proteins appear to be either structural components of large macromolecular chromatin complexes or proteins involved in remodelling chromatin structure. Recent work has suggested that apart from a role in regulating gene activity, chromodomain proteins may also play roles in genome organisation. This article reviews progress made in characterising mammalian chromodomain proteins and emphasises their emerging role in the regulation of gene expression and genome organisation. BioEssays 22:124-137, 2000.

KW - Amino Acid Sequence

KW - Animals

KW - Chromatin

KW - Chromosomal Proteins, Non-Histone

KW - Gene Expression

KW - Genome

KW - Humans

KW - Mice

KW - Models, Molecular

KW - Molecular Sequence Data

KW - Polycomb-Group Proteins

KW - Protein Conformation

KW - Repressor Proteins

KW - Sequence Homology, Amino Acid

KW - Journal Article

KW - Review

U2 - 10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E

DO - 10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E

M3 - Review article

VL - 22

SP - 124

EP - 137

JO - BioEssays

JF - BioEssays

SN - 0265-9247

IS - 2

ER -