Abstract
Modifiers of position-effect-variegation in Drosophila are thought to encode proteins that are either structural components of heterochromatin or enzymes that modify these components. We have recently shown that a sequence motif found in one Drosophila modifier gene, Heterochromatin protein 1 (HP1), is conserved in a wide variety of animal and plant species (Singh et al. 1991). Using this motif, termed chromo box, we have cloned a mouse candidate modifier gene, M31, that also shows considerable sequence homology to Drosophila HP1. Here we report evidence of at least four independently segregating loci in the mouse homologous to the M31 cDNA. One of these loci--Cbx-rs1--maps to the X Chromosome (Chr), 1 cM proximal to Amg and outside the X-inactivation center region.
| Original language | English |
|---|---|
| Pages (from-to) | 72-5 |
| Number of pages | 4 |
| Journal | Mammalian Genome |
| Volume | 2 |
| Issue number | 1 |
| Publication status | Published - 1992 |
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Keywords
- Animals
- Chromosome Mapping
- Crosses, Genetic
- Female
- Heterochromatin
- Male
- Mice
- Mice, Inbred C57BL
- Muridae
- Sequence Homology, Nucleic Acid
- X Chromosome
- Journal Article
- Research Support, Non-U.S. Gov't
Cite this
Mapping of a mouse homolog of a heterochromatin protein gene the X chromosome. / Hamvas, R M; Reik, W; Gaunt, S J; Brown, S D; Singh, P B.
In: Mammalian Genome, Vol. 2, No. 1, 1992, p. 72-5.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mapping of a mouse homolog of a heterochromatin protein gene the X chromosome
AU - Hamvas, R M
AU - Reik, W
AU - Gaunt, S J
AU - Brown, S D
AU - Singh, P B
PY - 1992
Y1 - 1992
N2 - Modifiers of position-effect-variegation in Drosophila are thought to encode proteins that are either structural components of heterochromatin or enzymes that modify these components. We have recently shown that a sequence motif found in one Drosophila modifier gene, Heterochromatin protein 1 (HP1), is conserved in a wide variety of animal and plant species (Singh et al. 1991). Using this motif, termed chromo box, we have cloned a mouse candidate modifier gene, M31, that also shows considerable sequence homology to Drosophila HP1. Here we report evidence of at least four independently segregating loci in the mouse homologous to the M31 cDNA. One of these loci--Cbx-rs1--maps to the X Chromosome (Chr), 1 cM proximal to Amg and outside the X-inactivation center region.
AB - Modifiers of position-effect-variegation in Drosophila are thought to encode proteins that are either structural components of heterochromatin or enzymes that modify these components. We have recently shown that a sequence motif found in one Drosophila modifier gene, Heterochromatin protein 1 (HP1), is conserved in a wide variety of animal and plant species (Singh et al. 1991). Using this motif, termed chromo box, we have cloned a mouse candidate modifier gene, M31, that also shows considerable sequence homology to Drosophila HP1. Here we report evidence of at least four independently segregating loci in the mouse homologous to the M31 cDNA. One of these loci--Cbx-rs1--maps to the X Chromosome (Chr), 1 cM proximal to Amg and outside the X-inactivation center region.
KW - Animals
KW - Chromosome Mapping
KW - Crosses, Genetic
KW - Female
KW - Heterochromatin
KW - Male
KW - Mice
KW - Mice, Inbred C57BL
KW - Muridae
KW - Sequence Homology, Nucleic Acid
KW - X Chromosome
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
M3 - Article
VL - 2
SP - 72
EP - 75
JO - Mammalian Genome
JF - Mammalian Genome
SN - 0938-8990
IS - 1
ER -