Mechanism of impaired glucose tolerance in patients with neoplasia

B. Jasani, L. J. Donaldson, J. G. Ratcliffe, G. S. Sokhi

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


The disappearance rate (k) of i.v. glucose was measured in cachectic and non-cachectic cancer patients and tumour-free controls. The respective k values were found to be 1.06±0.27 (mean±s.d.), 1.64± 0.34 and l.63±0.23. Of the other parameters measured, only plasma albumin level was found to vary significantly amongst the 3 categories, the mean level being the lowest in cachectic cancer patients. The means of total plasma protein, fasting blood glucose and plasma liver enzyme concentrations were similar in the 3 groups. Glucagon, a potent insulin secretogogue, failed to augment the fasting insulin level in cachectic but did so in non-cachectic cancer patients. Taken together, the findings suggest that the reduced glucose tolerance in patients with neoplasia is due to impairment of insulin release exhibited predominantly by ill-nourished advanced cancer patients having a moderate to severe degree of hypoalbuminemia.

Original languageEnglish
Pages (from-to)287-292
Number of pages6
JournalBritish journal of cancer
Issue number2
Publication statusPublished - Aug 1978
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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