Mechanisms of Gene Regulation: How Science Works

Carsten Carlberg, Ferdinand Molnár

Research output: Book/ReportBook

2 Citations (Scopus)

Abstract

This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. Th is pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.

Original languageEnglish
PublisherSpringer International Publishing
Number of pages149
ISBN (Electronic)9783030523213
ISBN (Print)9783030523206
DOIs
Publication statusPublished - Oct 29 2020

Keywords

  • Chromatin
  • DNA methylation
  • Epigenome
  • Histone modification
  • RNA
  • Transcription
  • Transcription factor

ASJC Scopus subject areas

  • General Medicine
  • General Biochemistry,Genetics and Molecular Biology

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