Medication Prescribing Patterns for Chronic Kidney Diseases: Analysis of Drug-Dose Adjustments, Polypharmacy, and Drug Interactions

Ainur Assan, Zakira Kerimbayeva, Ikilas Moldaliyev, Dmitriy Syssoyev, Ali Issayev, Aizat Seidakhmetova, Rita Assabayeva, Meruyert Madikenova, Dmitriy Sychev, Abduzhappar Gaipov

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Multiple drug prescriptions in chronic kidney disease (CKD) escalate metabolic buildup, nephrotoxicity, and end stage kidney disease progression. We aimed to study polypharmacy and harmful multi-drug interactions at the nephrology department of South-Kazakhstan Regional hospital. Methods: We analyzed electronic medical records of 485 patients with glomerular diseases (ICD-10 codes: N00-N08) admitted to the nephrology department from January 2018 to December 2021. We evaluated polypharmacy risk, dividing patients into low-risk, moderate-risk, and severe-risk groups based on the number of prescribed medications: 2-5, 6-9, and 10 or more, respectively. Additionally, we examined the occurrence and combinations of unsafe multi-drug interactions. Results: The study group included 45% CKD stage-1, 29% CKD stage-2, and 26% CKD stage-3 and above patients, with a median medication count of 9.5. Low-risk, moderate-risk, and severe-risk polypharmacy affected 12.2%, 48.2%, and 39.6% of patients, respectively. Inappropriate multi-drug combinations were particularly prevalent in early CKD stages. Notably, among commonly prescribed drugs, 19 out of 23 lacked dose adjustments according to the CKD stage. Conclusion: This pioneering study investigates polypharmacy and multi-drug interactions in CKD patients in Kazakhstan, revealing significant risks.

Original languageEnglish
Pages (from-to)324-332
Number of pages9
JournalTurkish Journal of Nephrology
Volume33
Issue number4
DOIs
Publication statusPublished - Oct 2024
Externally publishedYes

Keywords

  • Chronic kidney disease
  • dose adjustment
  • drug interactions
  • nephrotoxicity
  • polypharmacy

ASJC Scopus subject areas

  • Surgery
  • Nephrology
  • Transplantation

Fingerprint

Dive into the research topics of 'Medication Prescribing Patterns for Chronic Kidney Diseases: Analysis of Drug-Dose Adjustments, Polypharmacy, and Drug Interactions'. Together they form a unique fingerprint.

Cite this