TY - JOUR
T1 - Membrane biophysics and mechanics in alzheimer's disease
AU - Yang, Xiaoguang
AU - Askarova, Sholpan
AU - Lee, James C M
N1 - Funding Information:
Acknowledgements This work was supported by National Institutes of Health Grants 1P01AG18357, 1R21NS052385, and 1R21AG032579.
PY - 2010/6
Y1 - 2010/6
N2 - Alzheimer's disease is a chronic neurodegenerative disorder characterized by neuronal loss, cerebrovascular inflammation, and accumulation of senile plaques in the brain parenchyma and cerebral blood vessels. Amyloid-β peptide (Aβ), a major component of senile plaques, has been shown to exert multiple toxic effects to neurons, astrocytes, glial cells, and brain endothelium. Oligomeric Aβ can disturb the structure and function of cell membranes and alter membrane mechanical properties, such as membrane fluidity and molecular order. Much of these effects are attributed to their capability to trigger oxidative stress and inflammation. In this review, we discuss the effects of Aβ on neuronal cells, astrocytes, and cerebral endothelial cells with special emphasis on cell membrane properties and cell functions.
AB - Alzheimer's disease is a chronic neurodegenerative disorder characterized by neuronal loss, cerebrovascular inflammation, and accumulation of senile plaques in the brain parenchyma and cerebral blood vessels. Amyloid-β peptide (Aβ), a major component of senile plaques, has been shown to exert multiple toxic effects to neurons, astrocytes, glial cells, and brain endothelium. Oligomeric Aβ can disturb the structure and function of cell membranes and alter membrane mechanical properties, such as membrane fluidity and molecular order. Much of these effects are attributed to their capability to trigger oxidative stress and inflammation. In this review, we discuss the effects of Aβ on neuronal cells, astrocytes, and cerebral endothelial cells with special emphasis on cell membrane properties and cell functions.
KW - Alzheimer's disease
KW - Amyloid-β
KW - Cerebral endothelium
KW - Membrane fluidity
KW - Membrane order
KW - Membrane potential
KW - Membrane properties
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U2 - 10.1007/s12035-010-8121-9
DO - 10.1007/s12035-010-8121-9
M3 - Article
C2 - 20437210
AN - SCOPUS:77955060978
VL - 41
SP - 138
EP - 148
JO - Molecular Neurobiology
JF - Molecular Neurobiology
SN - 0893-7648
IS - 2-3
ER -