Membrane biophysics and mechanics in alzheimer's disease

Xiaoguang Yang, Sholpan Askarova, James C M Lee

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Alzheimer's disease is a chronic neurodegenerative disorder characterized by neuronal loss, cerebrovascular inflammation, and accumulation of senile plaques in the brain parenchyma and cerebral blood vessels. Amyloid-β peptide (Aβ), a major component of senile plaques, has been shown to exert multiple toxic effects to neurons, astrocytes, glial cells, and brain endothelium. Oligomeric Aβ can disturb the structure and function of cell membranes and alter membrane mechanical properties, such as membrane fluidity and molecular order. Much of these effects are attributed to their capability to trigger oxidative stress and inflammation. In this review, we discuss the effects of Aβ on neuronal cells, astrocytes, and cerebral endothelial cells with special emphasis on cell membrane properties and cell functions.

Original languageEnglish
Pages (from-to)138-148
Number of pages11
JournalMolecular Neurobiology
Volume41
Issue number2-3
DOIs
Publication statusPublished - Jun 2010
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Amyloid-β
  • Cerebral endothelium
  • Membrane fluidity
  • Membrane order
  • Membrane potential
  • Membrane properties

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

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