Mesenchymal stem cells modifications for enhanced bone targeting and bone regeneration

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3 Citations (Scopus)

Abstract

In pathological bone conditions (e.g., osteoporotic fractures or critical size bone defects), increasing the pool of osteoblast progenitor cells is a promising therapeutic approach to facilitate bone healing. Since mesenchymal stem cells (MSCs) give rise to the osteogenic lineage, a number of clinical trials investigated the potential of MSCs transplantation for bone regeneration. However, the engraftment of transplanted cells is often hindered by insufficient oxygen and nutrients supply and the tendency of MSCs to home to different sites of the body. In this review, we discuss various approaches of MSCs transplantation for bone regeneration including scaffold and hydrogel constructs, genetic modifications and surface engineering of the cell membrane aimed to improve homing and increase cell viability, proliferation and differentiation.

Original languageEnglish
Pages (from-to)1579-1594
Number of pages16
JournalRegenerative Medicine
Volume15
Issue number4
DOIs
Publication statusPublished - Apr 1 2020

Keywords

  • bone regeneration
  • cell surface engineering
  • genetic modifications
  • hydrogels
  • MSCs
  • scaffolds

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology

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