Abstract
In pathological bone conditions (e.g., osteoporotic fractures or critical size bone defects), increasing the pool of osteoblast progenitor cells is a promising therapeutic approach to facilitate bone healing. Since mesenchymal stem cells (MSCs) give rise to the osteogenic lineage, a number of clinical trials investigated the potential of MSCs transplantation for bone regeneration. However, the engraftment of transplanted cells is often hindered by insufficient oxygen and nutrients supply and the tendency of MSCs to home to different sites of the body. In this review, we discuss various approaches of MSCs transplantation for bone regeneration including scaffold and hydrogel constructs, genetic modifications and surface engineering of the cell membrane aimed to improve homing and increase cell viability, proliferation and differentiation.
| Original language | English |
|---|---|
| Pages (from-to) | 1579-1594 |
| Number of pages | 16 |
| Journal | Regenerative Medicine |
| Volume | 15 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 1 2020 |
Funding
This work was supported by Grant of the Ministry of Education and Science of the Republic of Kazakhstan No. 0118RK01040 and the CRP grant of Nazarbayev University No. 091019CRP2113. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
Keywords
- bone regeneration
- cell surface engineering
- genetic modifications
- hydrogels
- MSCs
- scaffolds
ASJC Scopus subject areas
- Biomedical Engineering
- Embryology
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