Mesoporous carbide-derived carbon for cytokine removal from blood plasma

Saujanya Yachamaneni, Gleb Yushin, Sun Hwa Yeon, Yury Gogotsi, Carol Howell, Susan Sandeman, Gary Phillips, Sergey Mikhalovsky

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Porous carbons can be used for purification of bio-fluids due to their excellent biocompatibility with blood. Since the ability to adsorb a range of inflammatory cytokines within the shortest possible time is crucial to stop the progression of sepsis, the improvement of the adsorption rate is a key factor to achieving efficient removal of cytokines. Here, we demonstrate the effect of synthesis temperatures (from 600°C to 1200°C), carbon particle sizes (from below 35μm to 300μm), and annealing conditions (Ar, NH3, H2, Cl2, and vacuum annealing) that determine the surface chemistry, on the ability of carbide-derived carbons (CDCs) to remove cytokines TNF-α, IL-6, and IL-1β from blood plasma. Optimization of CDC processing and structure leads to up to two orders of magnitude increase in the adsorption rate. Mesoporous CDCs that were produced at 800°C from Ti2AlC with the precursor particle size of 3, displayed complete removal of large molecules of TNF-α in less than an hour, with >85% and >95% TNF-α removal in 5 and 30min, respectively. This is a very significant improvement compared to the previously published results for CDC (90% TNF-α removal after 1h) and activated carbons. Smaller interleukin IL-6 and IL-1β molecules can be completely removed within 5min. These differences in adsorption rates show that carbons with controlled porosity can also be used for separation of protein molecules.

Original languageEnglish
Pages (from-to)4789-4794
Number of pages6
JournalBiomaterials
Volume31
Issue number18
DOIs
Publication statusPublished - Jun 2010
Externally publishedYes

Fingerprint

Carbides
Blood
Carbon
Cytokines
Plasmas
Adsorption
Interleukin-6
Interleukin-1
Molecules
Particle Size
Particle size
Annealing
Interleukins
Surface chemistry
Porosity
Biocompatibility
Activated carbon
Vacuum
Purification
Sepsis

Keywords

  • Carbide derived-carbon
  • Cytokine
  • MAX phase
  • Mesoporous carbon
  • Protein adsorption
  • Sepsis

ASJC Scopus subject areas

  • Biomaterials
  • Bioengineering
  • Ceramics and Composites
  • Mechanics of Materials
  • Biophysics

Cite this

Yachamaneni, S., Yushin, G., Yeon, S. H., Gogotsi, Y., Howell, C., Sandeman, S., ... Mikhalovsky, S. (2010). Mesoporous carbide-derived carbon for cytokine removal from blood plasma. Biomaterials, 31(18), 4789-4794. https://doi.org/10.1016/j.biomaterials.2010.02.054

Mesoporous carbide-derived carbon for cytokine removal from blood plasma. / Yachamaneni, Saujanya; Yushin, Gleb; Yeon, Sun Hwa; Gogotsi, Yury; Howell, Carol; Sandeman, Susan; Phillips, Gary; Mikhalovsky, Sergey.

In: Biomaterials, Vol. 31, No. 18, 06.2010, p. 4789-4794.

Research output: Contribution to journalArticle

Yachamaneni, S, Yushin, G, Yeon, SH, Gogotsi, Y, Howell, C, Sandeman, S, Phillips, G & Mikhalovsky, S 2010, 'Mesoporous carbide-derived carbon for cytokine removal from blood plasma', Biomaterials, vol. 31, no. 18, pp. 4789-4794. https://doi.org/10.1016/j.biomaterials.2010.02.054
Yachamaneni S, Yushin G, Yeon SH, Gogotsi Y, Howell C, Sandeman S et al. Mesoporous carbide-derived carbon for cytokine removal from blood plasma. Biomaterials. 2010 Jun;31(18):4789-4794. https://doi.org/10.1016/j.biomaterials.2010.02.054
Yachamaneni, Saujanya ; Yushin, Gleb ; Yeon, Sun Hwa ; Gogotsi, Yury ; Howell, Carol ; Sandeman, Susan ; Phillips, Gary ; Mikhalovsky, Sergey. / Mesoporous carbide-derived carbon for cytokine removal from blood plasma. In: Biomaterials. 2010 ; Vol. 31, No. 18. pp. 4789-4794.
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