Mesoporous carbide-derived carbon with porosity tuned for efficient adsorption of cytokines

Gleb Yushin, Elizabeth N. Hoffman, Michel W. Barsoum, Yury Gogotsi, Carol A. Howell, Susan R. Sandeman, Gary J. Phillips, Andrew W. Lloyd, Sergey V. Mikhalovsky

Research output: Contribution to journalArticlepeer-review

102 Citations (Scopus)

Abstract

Porous carbons can be used for the purification of various bio-fluids, including the cleansing blood of inflammatory mediators in conditions such as sepsis or auto-immune diseases. Here we show that the control of pore size in carbons is a key factor to achieving efficient removal of cytokines. In particular, the surface area accessible by the protein governs the rate and effectiveness of the adsorption process. We demonstrate that novel mesoporous carbon materials synthesized from ternary MAX-phase carbides can be optimized for efficient adsorption of large inflammatory proteins. The synthesized carbons, having tunable pore size with a large volume of slit-shaped mesopores, outperformed all other materials or methods in terms of efficiency of TNF-α removal and the results are comparable only with highly specific antibody-antigen interactions.

Original languageEnglish
Pages (from-to)5755-5762
Number of pages8
JournalBiomaterials
Volume27
Issue number34
DOIs
Publication statusPublished - Dec 1 2006

Keywords

  • Adsorption
  • Carbon
  • Cytokine
  • Protein adsorption

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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