Mesoporous silica decorated with gold nanoparticles as a promising nanoprobe for effective CT X-ray attenuation and potential drug delivery

Tomiris Mulikova, Aiganym Abduraimova, Anara Molkenova, Svetlana Em, Bakyt Duisenbayeva, Dong Wook Han, Timur Sh Atabaev

Research output: Contribution to journalArticlepeer-review

Abstract

The design of multifunctional agents became a pivotal task for the development of personalized medicine. In this study, we investigated the potential applicability of mesoporous silica decorated with gold nanoparticles (MS-Au NPs) for effective X-ray attenuation in computed tomography (CT) and as a potential vehicle for drug delivery. The physicochemical properties and X-ray attenuation efficiency of prepared MS-Au NPs were systematically studied using a range of characterization techniques and clinical CT correspondingly. CT analysis revealed that prepared MS-Au NPs exhibit high X-ray attenuation efficiency ∼9.8 HU/mM (Hounsfield Units per mM of Au) as compared to other perspective metal-based nanoparticles reported in the literature. An improved X-ray attenuation efficiency can be attributed to the presence of a large amount of Au nanoparticles in a confined volume unit.

Original languageEnglish
Article number100712
JournalNano-Structures and Nano-Objects
Volume26
DOIs
Publication statusPublished - Apr 2021

Keywords

  • Au nanoparticles
  • Computed tomography
  • Drug delivery
  • Mesoporous silica
  • X-ray attenuation

ASJC Scopus subject areas

  • Materials Science(all)
  • Physical and Theoretical Chemistry
  • Atomic and Molecular Physics, and Optics
  • Condensed Matter Physics

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