Mesoporous silica decorated with gold nanoparticles as a promising nanoprobe for effective CT X-ray attenuation and potential drug delivery

Tomiris Mulikova; Aiganym Abduraimova; Anara Molkenova; Svetlana Em; Bakyt Duisenbayeva; Dong Wook Han; Timur Sh Atabaev

doi:10.1016/j.nanoso.2021.100712

Mesoporous silica decorated with gold nanoparticles as a promising nanoprobe for effective CT X-ray attenuation and potential drug delivery

Tomiris Mulikova, Aiganym Abduraimova, Anara Molkenova, Svetlana Em, Bakyt Duisenbayeva, Dong Wook Han, Timur Sh Atabaev

Research output: Contribution to journal › Article › peer-review

Abstract

The design of multifunctional agents became a pivotal task for the development of personalized medicine. In this study, we investigated the potential applicability of mesoporous silica decorated with gold nanoparticles (MS-Au NPs) for effective X-ray attenuation in computed tomography (CT) and as a potential vehicle for drug delivery. The physicochemical properties and X-ray attenuation efficiency of prepared MS-Au NPs were systematically studied using a range of characterization techniques and clinical CT correspondingly. CT analysis revealed that prepared MS-Au NPs exhibit high X-ray attenuation efficiency ∼9.8 HU/mM (Hounsfield Units per mM of Au) as compared to other perspective metal-based nanoparticles reported in the literature. An improved X-ray attenuation efficiency can be attributed to the presence of a large amount of Au nanoparticles in a confined volume unit.

Original language	English
Article number	100712
Journal	Nano-Structures and Nano-Objects
Volume	26
DOIs	https://doi.org/10.1016/j.nanoso.2021.100712
Publication status	Published - Apr 2021

Keywords

Au nanoparticles
Computed tomography
Drug delivery
Mesoporous silica
X-ray attenuation

ASJC Scopus subject areas

Materials Science(all)
Physical and Theoretical Chemistry
Atomic and Molecular Physics, and Optics
Condensed Matter Physics

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Mesoporous silica decorated with gold nanoparticles as a promising nanoprobe for effective CT X-ray attenuation and potential drug delivery. / Mulikova, Tomiris; Abduraimova, Aiganym; Molkenova, Anara; Em, Svetlana; Duisenbayeva, Bakyt; Han, Dong Wook; Atabaev, Timur Sh.

In: Nano-Structures and Nano-Objects, Vol. 26, 100712, 04.2021.

Research output: Contribution to journal › Article › peer-review

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abstract = "The design of multifunctional agents became a pivotal task for the development of personalized medicine. In this study, we investigated the potential applicability of mesoporous silica decorated with gold nanoparticles (MS-Au NPs) for effective X-ray attenuation in computed tomography (CT) and as a potential vehicle for drug delivery. The physicochemical properties and X-ray attenuation efficiency of prepared MS-Au NPs were systematically studied using a range of characterization techniques and clinical CT correspondingly. CT analysis revealed that prepared MS-Au NPs exhibit high X-ray attenuation efficiency ∼9.8 HU/mM (Hounsfield Units per mM of Au) as compared to other perspective metal-based nanoparticles reported in the literature. An improved X-ray attenuation efficiency can be attributed to the presence of a large amount of Au nanoparticles in a confined volume unit.",

keywords = "Au nanoparticles, Computed tomography, Drug delivery, Mesoporous silica, X-ray attenuation",

author = "Tomiris Mulikova and Aiganym Abduraimova and Anara Molkenova and Svetlana Em and Bakyt Duisenbayeva and Han, {Dong Wook} and Atabaev, {Timur Sh}",

note = "Funding Information: Tomiris Mulikova, Aiganym Abduraimova and Svetlana Em would like to acknowledge the support of NPO Young Researchers Alliance and Nazarbayev University Corporate Fund “Social Development Fund”, Republic of Kazakhstan for grant under their Fostering Research and Innovation Potential Program. This study was also funded by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2019R1A4A1024116 ). Publisher Copyright: {\textcopyright} 2021 Elsevier B.V. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

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doi = "10.1016/j.nanoso.2021.100712",

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AU - Mulikova, Tomiris

AU - Abduraimova, Aiganym

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AU - Em, Svetlana

AU - Duisenbayeva, Bakyt

AU - Han, Dong Wook

AU - Atabaev, Timur Sh

N1 - Funding Information: Tomiris Mulikova, Aiganym Abduraimova and Svetlana Em would like to acknowledge the support of NPO Young Researchers Alliance and Nazarbayev University Corporate Fund “Social Development Fund”, Republic of Kazakhstan for grant under their Fostering Research and Innovation Potential Program. This study was also funded by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2019R1A4A1024116 ). Publisher Copyright: © 2021 Elsevier B.V. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/4

Y1 - 2021/4

N2 - The design of multifunctional agents became a pivotal task for the development of personalized medicine. In this study, we investigated the potential applicability of mesoporous silica decorated with gold nanoparticles (MS-Au NPs) for effective X-ray attenuation in computed tomography (CT) and as a potential vehicle for drug delivery. The physicochemical properties and X-ray attenuation efficiency of prepared MS-Au NPs were systematically studied using a range of characterization techniques and clinical CT correspondingly. CT analysis revealed that prepared MS-Au NPs exhibit high X-ray attenuation efficiency ∼9.8 HU/mM (Hounsfield Units per mM of Au) as compared to other perspective metal-based nanoparticles reported in the literature. An improved X-ray attenuation efficiency can be attributed to the presence of a large amount of Au nanoparticles in a confined volume unit.

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