Methods for quantitating hla gene product expression in the liver during Hepatitis B Virus infection

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1 Citation (Scopus)

Abstract

HLA antigens play an important role in the immunological responses to transplanted organs and in tumor surveillance and antiviral immunity. In several liver diseases qualitative and quantitative changes in the HLA gene product expression can be found on hepatocytes, bile duct epithelium and sinusoidal lining cells and these changes may affect the efficacy of the immune system in recognizing an exogenous antigen. In this paper we describe methods for quantitating the changes in HLA antigen expression occurring in the liver during various phases of hepatitis B virus infection and the way in which we have attempted to identify possible mechanisms leading to chronicity.

Original languageEnglish
Pages (from-to)233-239
Number of pages7
JournalLa Ricerca in Clinica e in Laboratorio
Volume18
Issue number2-3
DOIs
Publication statusPublished - Apr 1988
Externally publishedYes

Fingerprint

Virus Diseases
HLA Antigens
Viruses
Hepatitis B virus
Liver
Genes
Gene Expression
Immune system
Bile Ducts
Linings
Ducts
Antiviral Agents
Liver Diseases
Tumors
Hepatocytes
Immune System
Immunity
Epithelium
Antigens
Neoplasms

Keywords

  • Collagenase
  • Hepatitis B virus
  • HLA
  • Immunofluorescence
  • Microphotometer
  • Monoclonal antibodies
  • Radioimmunobinding

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

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abstract = "HLA antigens play an important role in the immunological responses to transplanted organs and in tumor surveillance and antiviral immunity. In several liver diseases qualitative and quantitative changes in the HLA gene product expression can be found on hepatocytes, bile duct epithelium and sinusoidal lining cells and these changes may affect the efficacy of the immune system in recognizing an exogenous antigen. In this paper we describe methods for quantitating the changes in HLA antigen expression occurring in the liver during various phases of hepatitis B virus infection and the way in which we have attempted to identify possible mechanisms leading to chronicity.",
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AB - HLA antigens play an important role in the immunological responses to transplanted organs and in tumor surveillance and antiviral immunity. In several liver diseases qualitative and quantitative changes in the HLA gene product expression can be found on hepatocytes, bile duct epithelium and sinusoidal lining cells and these changes may affect the efficacy of the immune system in recognizing an exogenous antigen. In this paper we describe methods for quantitating the changes in HLA antigen expression occurring in the liver during various phases of hepatitis B virus infection and the way in which we have attempted to identify possible mechanisms leading to chronicity.

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KW - Radioimmunobinding

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