Microfluidic fabrication of perfluorohexane-shelled double emulsions for controlled loading and acoustic-triggered release of hydrophilic agents

Wynter J. Duncanson, Laura R. Arriaga, W. Lloyd Ung, Jonathan A. Kopechek, Tyrone M. Porter, David A. Weitz

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The ability of low boiling point liquid perfluorocarbons (PFCs) to undergo a phase change from a liquid to a gas upon ultrasound irradiation makes PFC-based emulsions promising vehicles for triggered delivery of payloads. However, loading hydrophilic agents into PFC-based emulsions is difficult due to their insolubility in PFC. Here, we address this challenge by taking advantage of microfluidic technologies to fabricate double emulsions consisting of large aqueous cores and a perfluorohexane (PFH) shell, thus yielding high loading capacities for hydrophilic agents. Using this technology, we efficiently encapsulate a model hydrophilic agent within the emulsions and study its response to ultrasound irradiation. Using a combination of optical and acoustic imaging methods, we observe payload release upon acoustic vaporization of PFH. Our work demonstrates the utility of microfluidic techniques for controllably loading hydrophilic agents into PFH-based emulsions, which have great potential for acoustically triggered release.

Original languageEnglish
Pages (from-to)13765-13770
Number of pages6
JournalLangmuir
Volume30
Issue number46
DOIs
Publication statusPublished - Nov 25 2014

Fingerprint

Microfluidics
Fluorocarbons
Emulsions
Acoustics
emulsions
Fabrication
fabrication
acoustics
payloads
Ultrasonics
Irradiation
Acoustic imaging
acoustic imaging
Technology
Volatilization
irradiation
Optical Imaging
Boiling point
Liquids
liquids

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy
  • Medicine(all)

Cite this

Duncanson, W. J., Arriaga, L. R., Ung, W. L., Kopechek, J. A., Porter, T. M., & Weitz, D. A. (2014). Microfluidic fabrication of perfluorohexane-shelled double emulsions for controlled loading and acoustic-triggered release of hydrophilic agents. Langmuir, 30(46), 13765-13770. https://doi.org/10.1021/la502473w

Microfluidic fabrication of perfluorohexane-shelled double emulsions for controlled loading and acoustic-triggered release of hydrophilic agents. / Duncanson, Wynter J.; Arriaga, Laura R.; Ung, W. Lloyd; Kopechek, Jonathan A.; Porter, Tyrone M.; Weitz, David A.

In: Langmuir, Vol. 30, No. 46, 25.11.2014, p. 13765-13770.

Research output: Contribution to journalArticle

Duncanson, Wynter J. ; Arriaga, Laura R. ; Ung, W. Lloyd ; Kopechek, Jonathan A. ; Porter, Tyrone M. ; Weitz, David A. / Microfluidic fabrication of perfluorohexane-shelled double emulsions for controlled loading and acoustic-triggered release of hydrophilic agents. In: Langmuir. 2014 ; Vol. 30, No. 46. pp. 13765-13770.
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