Microfluidic synthesis of monodisperse porous microspheres with size-tunable pores

Wynter J. Duncanson, Maximilian Zieringer, Olaf Wagner, James N. Wilking, Alireza Abbaspourrad, Rainer Haag, David A. Weitz

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

We use a perfluorinated-dendrimer-dye complex that stabilizes microbubbles as a novel pore-forming agent. We use microfluidics to produce monodisperse emulsions containing a polymer matrix material, a model active, and the perfluorinated complex; upon drying, the emulsions form porous microspheres. This porosity causes the encapsulated model active to be released faster than from non-porous microspheres. Moreover, because of the fluorous features of the pores, we can also attach an additional guest molecule to the pores which is released with a profile that is distinct from that of the encapsulated active. These porous microspheres can encapsulate and controllably release multiple actives; this makes them valuable for applications such as drug delivery and imaging.

Original languageEnglish
Pages (from-to)10636-10640
Number of pages5
JournalSoft Matter
Volume8
Issue number41
DOIs
Publication statusPublished - Nov 7 2012

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

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