Abstract
There is a rapidly growing body of evidence that production of microvesicles (MVs) is a universal feature of cellular life. MVs can incorporate microRNA (miRNA), mRNA, mtDNA, DNA and retrotransposons, camouflage viruses/viral components from immune surveillance, and transfer cargo between cells. These properties make MVs an essential player in intercellular communication. Increasing evidence supports the notion that MVs can also act as long-distance vehicles for RNA molecules and participate in metabolic synchronization and reprogramming eukaryotic cells including stem and germinal cells. MV ability to carry on DNA and their general distribution makes them attractive candidates for horizontal gene transfer, particularly between multi-cellular organisms and their parasites; this suggests important implications for the co-evolution of parasites and their hosts. In this review, we provide current understanding of the roles played by MVs in intracellular pathogens and parasitic infections. We also discuss the possible role of MVs in co-infection and host shifting.
| Original language | English |
|---|---|
| Article number | Article 49 |
| Journal | Frontiers in cellular and infection microbiology |
| Volume | 4 |
| Issue number | SEP |
| DOIs | |
| Publication status | Published - 2013 |
| Externally published | Yes |
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Keywords
- Co-infection
- Exosomes
- Horizontal gene transfer
- Metabolism synchronization
- Microvesicles
- MiRNA
- Parasite
- Plasmodium
ASJC Scopus subject areas
- Microbiology
- Microbiology (medical)
- Infectious Diseases
- Immunology
- Medicine(all)
Cite this
Microvesicles and intercellular communication in the context of parasitism. / Barteneva, Natasha S.; Maltsev, Natalia; Vorobjev, Ivan A.
In: Frontiers in cellular and infection microbiology, Vol. 4, No. SEP, Article 49, 2013.Research output: Contribution to journal › Short survey
}
TY - JOUR
T1 - Microvesicles and intercellular communication in the context of parasitism
AU - Barteneva, Natasha S.
AU - Maltsev, Natalia
AU - Vorobjev, Ivan A.
PY - 2013
Y1 - 2013
N2 - There is a rapidly growing body of evidence that production of microvesicles (MVs) is a universal feature of cellular life. MVs can incorporate microRNA (miRNA), mRNA, mtDNA, DNA and retrotransposons, camouflage viruses/viral components from immune surveillance, and transfer cargo between cells. These properties make MVs an essential player in intercellular communication. Increasing evidence supports the notion that MVs can also act as long-distance vehicles for RNA molecules and participate in metabolic synchronization and reprogramming eukaryotic cells including stem and germinal cells. MV ability to carry on DNA and their general distribution makes them attractive candidates for horizontal gene transfer, particularly between multi-cellular organisms and their parasites; this suggests important implications for the co-evolution of parasites and their hosts. In this review, we provide current understanding of the roles played by MVs in intracellular pathogens and parasitic infections. We also discuss the possible role of MVs in co-infection and host shifting.
AB - There is a rapidly growing body of evidence that production of microvesicles (MVs) is a universal feature of cellular life. MVs can incorporate microRNA (miRNA), mRNA, mtDNA, DNA and retrotransposons, camouflage viruses/viral components from immune surveillance, and transfer cargo between cells. These properties make MVs an essential player in intercellular communication. Increasing evidence supports the notion that MVs can also act as long-distance vehicles for RNA molecules and participate in metabolic synchronization and reprogramming eukaryotic cells including stem and germinal cells. MV ability to carry on DNA and their general distribution makes them attractive candidates for horizontal gene transfer, particularly between multi-cellular organisms and their parasites; this suggests important implications for the co-evolution of parasites and their hosts. In this review, we provide current understanding of the roles played by MVs in intracellular pathogens and parasitic infections. We also discuss the possible role of MVs in co-infection and host shifting.
KW - Co-infection
KW - Exosomes
KW - Horizontal gene transfer
KW - Metabolism synchronization
KW - Microvesicles
KW - MiRNA
KW - Parasite
KW - Plasmodium
UR - http://www.scopus.com/inward/record.url?scp=84891546204&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891546204&partnerID=8YFLogxK
U2 - 10.3389/fcimb.2013.00049
DO - 10.3389/fcimb.2013.00049
M3 - Short survey
C2 - 24032108
AN - SCOPUS:84891546204
VL - 4
JO - Frontiers in cellular and infection microbiology
JF - Frontiers in cellular and infection microbiology
SN - 2235-2988
IS - SEP
M1 - Article 49
ER -