Microvesicles and intercellular communication in the context of parasitism

Research output: Contribution to journalShort survey

54 Citations (Scopus)

Abstract

There is a rapidly growing body of evidence that production of microvesicles (MVs) is a universal feature of cellular life. MVs can incorporate microRNA (miRNA), mRNA, mtDNA, DNA and retrotransposons, camouflage viruses/viral components from immune surveillance, and transfer cargo between cells. These properties make MVs an essential player in intercellular communication. Increasing evidence supports the notion that MVs can also act as long-distance vehicles for RNA molecules and participate in metabolic synchronization and reprogramming eukaryotic cells including stem and germinal cells. MV ability to carry on DNA and their general distribution makes them attractive candidates for horizontal gene transfer, particularly between multi-cellular organisms and their parasites; this suggests important implications for the co-evolution of parasites and their hosts. In this review, we provide current understanding of the roles played by MVs in intracellular pathogens and parasitic infections. We also discuss the possible role of MVs in co-infection and host shifting.

Original languageEnglish
Article numberArticle 49
JournalFrontiers in cellular and infection microbiology
Volume4
Issue numberSEP
DOIs
Publication statusPublished - 2013
Externally publishedYes

Fingerprint

Viral Structures
Parasites
Horizontal Gene Transfer
Retroelements
Parasitic Diseases
DNA
Eukaryotic Cells
MicroRNAs
Coinfection
Mitochondrial DNA
Stem Cells
RNA
Messenger RNA

Keywords

  • Co-infection
  • Exosomes
  • Horizontal gene transfer
  • Metabolism synchronization
  • Microvesicles
  • MiRNA
  • Parasite
  • Plasmodium

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Immunology
  • Medicine(all)

Cite this

Microvesicles and intercellular communication in the context of parasitism. / Barteneva, Natasha S.; Maltsev, Natalia; Vorobjev, Ivan A.

In: Frontiers in cellular and infection microbiology, Vol. 4, No. SEP, Article 49, 2013.

Research output: Contribution to journalShort survey

@article{8f4db76d3ea54aff960c18966e37675a,
title = "Microvesicles and intercellular communication in the context of parasitism",
abstract = "There is a rapidly growing body of evidence that production of microvesicles (MVs) is a universal feature of cellular life. MVs can incorporate microRNA (miRNA), mRNA, mtDNA, DNA and retrotransposons, camouflage viruses/viral components from immune surveillance, and transfer cargo between cells. These properties make MVs an essential player in intercellular communication. Increasing evidence supports the notion that MVs can also act as long-distance vehicles for RNA molecules and participate in metabolic synchronization and reprogramming eukaryotic cells including stem and germinal cells. MV ability to carry on DNA and their general distribution makes them attractive candidates for horizontal gene transfer, particularly between multi-cellular organisms and their parasites; this suggests important implications for the co-evolution of parasites and their hosts. In this review, we provide current understanding of the roles played by MVs in intracellular pathogens and parasitic infections. We also discuss the possible role of MVs in co-infection and host shifting.",
keywords = "Co-infection, Exosomes, Horizontal gene transfer, Metabolism synchronization, Microvesicles, MiRNA, Parasite, Plasmodium",
author = "Barteneva, {Natasha S.} and Natalia Maltsev and Vorobjev, {Ivan A.}",
year = "2013",
doi = "10.3389/fcimb.2013.00049",
language = "English",
volume = "4",
journal = "Frontiers in cellular and infection microbiology",
issn = "2235-2988",
publisher = "Frontiers Media S. A.",
number = "SEP",

}

TY - JOUR

T1 - Microvesicles and intercellular communication in the context of parasitism

AU - Barteneva, Natasha S.

AU - Maltsev, Natalia

AU - Vorobjev, Ivan A.

PY - 2013

Y1 - 2013

N2 - There is a rapidly growing body of evidence that production of microvesicles (MVs) is a universal feature of cellular life. MVs can incorporate microRNA (miRNA), mRNA, mtDNA, DNA and retrotransposons, camouflage viruses/viral components from immune surveillance, and transfer cargo between cells. These properties make MVs an essential player in intercellular communication. Increasing evidence supports the notion that MVs can also act as long-distance vehicles for RNA molecules and participate in metabolic synchronization and reprogramming eukaryotic cells including stem and germinal cells. MV ability to carry on DNA and their general distribution makes them attractive candidates for horizontal gene transfer, particularly between multi-cellular organisms and their parasites; this suggests important implications for the co-evolution of parasites and their hosts. In this review, we provide current understanding of the roles played by MVs in intracellular pathogens and parasitic infections. We also discuss the possible role of MVs in co-infection and host shifting.

AB - There is a rapidly growing body of evidence that production of microvesicles (MVs) is a universal feature of cellular life. MVs can incorporate microRNA (miRNA), mRNA, mtDNA, DNA and retrotransposons, camouflage viruses/viral components from immune surveillance, and transfer cargo between cells. These properties make MVs an essential player in intercellular communication. Increasing evidence supports the notion that MVs can also act as long-distance vehicles for RNA molecules and participate in metabolic synchronization and reprogramming eukaryotic cells including stem and germinal cells. MV ability to carry on DNA and their general distribution makes them attractive candidates for horizontal gene transfer, particularly between multi-cellular organisms and their parasites; this suggests important implications for the co-evolution of parasites and their hosts. In this review, we provide current understanding of the roles played by MVs in intracellular pathogens and parasitic infections. We also discuss the possible role of MVs in co-infection and host shifting.

KW - Co-infection

KW - Exosomes

KW - Horizontal gene transfer

KW - Metabolism synchronization

KW - Microvesicles

KW - MiRNA

KW - Parasite

KW - Plasmodium

UR - http://www.scopus.com/inward/record.url?scp=84891546204&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891546204&partnerID=8YFLogxK

U2 - 10.3389/fcimb.2013.00049

DO - 10.3389/fcimb.2013.00049

M3 - Short survey

VL - 4

JO - Frontiers in cellular and infection microbiology

JF - Frontiers in cellular and infection microbiology

SN - 2235-2988

IS - SEP

M1 - Article 49

ER -