Mitochondrial Aging: Is There a Mitochondrial Clock?

Dmitry B. Zorov, Vasily A. Popkov, Ljubava D. Zorova, Ivan Vorobyev, Irina B. Pevzner, Denis N. Silachev, Savva D. Zorov, Stanislovas S. Jankauskas, Valentina A. Babenko, Egor Y. Plotnikov

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Fragmentation (fission) of mitochondria, occurring in response to oxidative challenge, leads to heterogeneity in the mitochondrial population. It is assumed that fission provides a way to segregate mitochondrial content between the "young" and "old" phenotype, with the formation of mitochondrial "garbage," which later will be disposed. Fidelity of this process is the basis of mitochondrial homeostasis, which is disrupted in pathological conditions and aging. The asymmetry of the mitochondrial fission is similar to that of their evolutionary ancestors, bacteria, which also undergo an aging process. It is assumed that mitochondrial markers of aging are recognized by the mitochondrial quality control system, preventing the accumulation of dysfunctional mitochondria, which normally are subjected to disposal. Possibly, oncocytoma, with its abnormal proliferation of mitochondria occupying the entire cytoplasm, represents the case when segregation of damaged mitochondria is impaired during mitochondrial division. It is plausible that mitochondria contain a "clock" which counts the degree of mitochondrial senescence as the extent of flagging (by ubiquitination) of damaged mitochondria. Mitochondrial aging captures the essence of the systemic aging which must be analyzed. We assume that the mitochondrial aging mechanism is similar to the mechanism of aging of the immune system which we discuss in detail.

Original languageEnglish
Pages (from-to)1171-1179
Number of pages9
JournalThe journals of gerontology. Series A, Biological sciences and medical sciences
Volume72
Issue number9
DOIs
Publication statusPublished - Sep 1 2017

Keywords

  • Autophagy
  • Biology of aging
  • Cellular senescence
  • Mitochondria
  • Mitophagy

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

Fingerprint Dive into the research topics of 'Mitochondrial Aging: Is There a Mitochondrial Clock?'. Together they form a unique fingerprint.

  • Cite this

    Zorov, D. B., Popkov, V. A., Zorova, L. D., Vorobyev, I., Pevzner, I. B., Silachev, D. N., Zorov, S. D., Jankauskas, S. S., Babenko, V. A., & Plotnikov, E. Y. (2017). Mitochondrial Aging: Is There a Mitochondrial Clock? The journals of gerontology. Series A, Biological sciences and medical sciences, 72(9), 1171-1179. https://doi.org/10.1093/gerona/glw184