Modulation of cell adhesion during epithelial restitution in the gastrointestinal tract

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Epithelial migration, which is a fundamental component of the ulcer healing process, is characterized by complex alterations in adhesion between cells and the extracellular matrix. Growth and motility factors involved in mucosal repair of the gastrointestinal tract seem to modulate these interactions in a coordinated fashion in order to reestablish functional and structural integrity of the mucosa. These findings may have important clinical implications for the treatment of ulcerative conditions of the gastrointestinal tract and lead to the development of specific drugs that promote mucosal healing by exploiting natural mechanisms of cell migration.

Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalYale Journal of Biology and Medicine
Volume69
Issue number2
Publication statusPublished - Mar 1996
Externally publishedYes

Fingerprint

Cell adhesion
Structural integrity
Cell Adhesion
Gastrointestinal Tract
Repair
Modulation
Pharmaceutical Preparations
Ulcer
Cell Movement
Extracellular Matrix
Intercellular Signaling Peptides and Proteins
Mucous Membrane

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Modulation of cell adhesion during epithelial restitution in the gastrointestinal tract. / Pignatelli, Massimo.

In: Yale Journal of Biology and Medicine, Vol. 69, No. 2, 03.1996, p. 131-135.

Research output: Contribution to journalArticle

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