Molecular Aspects of Allergen-Specific Immunotherapy in Patients with Seasonal Allergic Rhinitis

Marina Izmailovich; Yuliya Semenova; Gulzada Abdushukurova; Ainur Mukhamejanova; Azhar Dyussupova; Raida Faizova; Meruert Gazaliyeva; Leila Akhvlediani; Natalya Glushkova; Sundetgali Kalmakhanov; Geir Bjørklund

doi:10.3390/cells12030383

Molecular Aspects of Allergen-Specific Immunotherapy in Patients with Seasonal Allergic Rhinitis

Marina Izmailovich, Yuliya Semenova, Gulzada Abdushukurova, Ainur Mukhamejanova, Azhar Dyussupova, Raida Faizova, Meruert Gazaliyeva, Leila Akhvlediani, Natalya Glushkova, Sundetgali Kalmakhanov, Geir Bjørklund

Research output: Contribution to journal › Review article › peer-review

12 Citations (Scopus)

Abstract

A systematic review and narrative synthesis of publications was undertaken to analyze the role of component-resolved diagnosis technology in identifying polysensitization for the provision of allergen-specific immunotherapy to patients with seasonal allergic rhinitis. A search of publications was carried out in electronic databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The search helped to identify 568 publications, 12 of which were included in this review. Overall, 3302 patients were enrolled. The major finding was that component-resolved diagnostics change the choice of relevant allergens for allergen-specific immunotherapy in at least 50% of cases. Sensitization to allergen components differs with age, type of disease, and overall disease duration. Patients who had both bronchial asthma and allergic rhinitis were sensitized to a larger number of allergens than patients who had bronchial asthma alone.

Original language	English
Journal	Cells
Volume	12
Issue number	3
DOIs	https://doi.org/10.3390/cells12030383
Publication status	Published - Jan 20 2023

Keywords

Humans
Rhinitis, Allergic, Seasonal/therapy
Allergens
Rhinitis, Allergic/diagnosis
Desensitization, Immunologic
Asthma/diagnosis

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10.3390/cells12030383

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title = "Molecular Aspects of Allergen-Specific Immunotherapy in Patients with Seasonal Allergic Rhinitis",

abstract = "A systematic review and narrative synthesis of publications was undertaken to analyze the role of component-resolved diagnosis technology in identifying polysensitization for the provision of allergen-specific immunotherapy to patients with seasonal allergic rhinitis. A search of publications was carried out in electronic databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The search helped to identify 568 publications, 12 of which were included in this review. Overall, 3302 patients were enrolled. The major finding was that component-resolved diagnostics change the choice of relevant allergens for allergen-specific immunotherapy in at least 50% of cases. Sensitization to allergen components differs with age, type of disease, and overall disease duration. Patients who had both bronchial asthma and allergic rhinitis were sensitized to a larger number of allergens than patients who had bronchial asthma alone.",

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author = "Marina Izmailovich and Yuliya Semenova and Gulzada Abdushukurova and Ainur Mukhamejanova and Azhar Dyussupova and Raida Faizova and Meruert Gazaliyeva and Leila Akhvlediani and Natalya Glushkova and Sundetgali Kalmakhanov and Geir Bj{\o}rklund",

year = "2023",

month = jan,

day = "20",

doi = "10.3390/cells12030383",

language = "English",

volume = "12",

journal = "Cells",

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T1 - Molecular Aspects of Allergen-Specific Immunotherapy in Patients with Seasonal Allergic Rhinitis

AU - Izmailovich, Marina

AU - Semenova, Yuliya

AU - Abdushukurova, Gulzada

AU - Mukhamejanova, Ainur

AU - Dyussupova, Azhar

AU - Faizova, Raida

AU - Gazaliyeva, Meruert

AU - Akhvlediani, Leila

AU - Glushkova, Natalya

AU - Kalmakhanov, Sundetgali

AU - Bjørklund, Geir

PY - 2023/1/20

Y1 - 2023/1/20

N2 - A systematic review and narrative synthesis of publications was undertaken to analyze the role of component-resolved diagnosis technology in identifying polysensitization for the provision of allergen-specific immunotherapy to patients with seasonal allergic rhinitis. A search of publications was carried out in electronic databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The search helped to identify 568 publications, 12 of which were included in this review. Overall, 3302 patients were enrolled. The major finding was that component-resolved diagnostics change the choice of relevant allergens for allergen-specific immunotherapy in at least 50% of cases. Sensitization to allergen components differs with age, type of disease, and overall disease duration. Patients who had both bronchial asthma and allergic rhinitis were sensitized to a larger number of allergens than patients who had bronchial asthma alone.

AB - A systematic review and narrative synthesis of publications was undertaken to analyze the role of component-resolved diagnosis technology in identifying polysensitization for the provision of allergen-specific immunotherapy to patients with seasonal allergic rhinitis. A search of publications was carried out in electronic databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The search helped to identify 568 publications, 12 of which were included in this review. Overall, 3302 patients were enrolled. The major finding was that component-resolved diagnostics change the choice of relevant allergens for allergen-specific immunotherapy in at least 50% of cases. Sensitization to allergen components differs with age, type of disease, and overall disease duration. Patients who had both bronchial asthma and allergic rhinitis were sensitized to a larger number of allergens than patients who had bronchial asthma alone.

KW - Humans

KW - Rhinitis, Allergic, Seasonal/therapy

KW - Allergens

KW - Rhinitis, Allergic/diagnosis

KW - Desensitization, Immunologic

KW - Asthma/diagnosis

U2 - 10.3390/cells12030383

DO - 10.3390/cells12030383

M3 - Review article

C2 - 36766723

SN - 2073-4409

VL - 12

JO - Cells

JF - Cells

IS - 3

ER -

Molecular Aspects of Allergen-Specific Immunotherapy in Patients with Seasonal Allergic Rhinitis

Abstract

Keywords

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