Molecular biology: The transcriptional landscape of the mammalian genome

FANTOM Consortium

Research output: Contribution to journalArticlepeer-review

2517 Citations (Scopus)


This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5′ and 3′ boundaries of 181.047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.

Original languageEnglish
Pages (from-to)1559-1563
Number of pages5
Issue number5740
Publication statusPublished - Sep 2 2005

ASJC Scopus subject areas

  • General

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