Molecular epidemiology of Mycobacterium tuberculosis strains circulating in the penitentiary system of Kazakhstan

A. Ibrayeva, U. Kozhamkulov, D. Raiymbek, A. Alenova, S. Igilikova, E. Zholdybayeva, T. Abildaev, K. Momynaliev

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A total of 60 Mycobacterium tuberculosis isolates collected from patients in prisons in Kazakhstan and 125 from the civilian sector were examined using mycobacterial interspersed repetitive units-variable number of tandem repeat analysis in 2012. The proportion of tuberculosis strains with unique genotypes isolated from the civilian patients was 50.4%, while that in the prison patients was 31.7%. This difference was statistically significant (χ2 4.42, P = 0.035), and may reflect a low genetic diversity of M. tuberculosis strains isolated from prison patients. The frequencies of mutations in the rpoB531 and katG315 genes of the M. tuberculosis strains isolated from the civilians and in the penitentiary system were not significantly different (rpoB531: 82.4% vs. 88.3%, and katG315: 98.4% vs. 100%, respectively).

Original languageEnglish
Pages (from-to)298-301
Number of pages4
JournalInternational Journal of Tuberculosis and Lung Disease
Volume18
Issue number3
DOIs
Publication statusPublished - Mar 1 2014

    Fingerprint

Keywords

  • DNA sequencing
  • MIRU-VNTR genotyping
  • Mycobacterium tuberculosis
  • Penitentiary system

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this