Molecular evolution and phylogeny of elapid snake venom three-finger toxins

Bryan Grieg Fry, W. Wüster, R. M. Kini, V. Brusic, A. Khan, D. Venkataraman, A. P. Rooney

Research output: Contribution to journalArticle

220 Citations (Scopus)

Abstract

Animal venom components are of considerable interest to researchers across a wide variety of disciplines, including molecular biology, biochemistry, medicine, and evolutionary genetics. The three-finger family of snake venom peptides is a particularly interesting and biochemically complex group of venom peptides, because they are encoded by a large multigene family and display a diverse array of functional activities. In addition, understanding how this complex and highly varied multi-gene family evolved is an interesting question to researchers investigating the biochemical diversity of these peptides and their impact on human health. Therefore, the purpose of our study was to investigate the long-term evolutionary patterns exhibited by these snake venom toxins to understand the mechanisms by which they diversified into a large, biochemically diverse, multigene family. Our results show a much greater diversity of family members than was previously known, including a number of subfamilies that did not fall within any previously identified groups with characterized activities. In addition, we found that the long-term evolutionary processes that gave rise to the diversity of three-finger toxins are consistent with the birth-and-death model of multigene family evolution. It is anticipated that this "three-finger toxin toolkit" will prove to be useful in providing a clearer picture of the diversity of investigational ligands or potential therapeutics available within this important family.

Original languageEnglish
Pages (from-to)110-129
Number of pages20
JournalJournal of Molecular Evolution
Volume57
Issue number1
DOIs
Publication statusPublished - Jul 1 2003
Externally publishedYes

Fingerprint

Elapid Venoms
venom
Snake Venoms
Molecular Evolution
venoms
Phylogeny
Multigene Family
snake
multigene family
snakes
toxin
Fingers
phylogeny
toxins
Venoms
Peptides
peptides
Research Personnel
Biochemistry
peptide

Keywords

  • Elapidae
  • Multigene family
  • Three-finger toxin
  • Venom

ASJC Scopus subject areas

  • Genetics
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Genetics(clinical)
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)

Cite this

Fry, B. G., Wüster, W., Kini, R. M., Brusic, V., Khan, A., Venkataraman, D., & Rooney, A. P. (2003). Molecular evolution and phylogeny of elapid snake venom three-finger toxins. Journal of Molecular Evolution, 57(1), 110-129. https://doi.org/10.1007/s00239-003-2461-2

Molecular evolution and phylogeny of elapid snake venom three-finger toxins. / Fry, Bryan Grieg; Wüster, W.; Kini, R. M.; Brusic, V.; Khan, A.; Venkataraman, D.; Rooney, A. P.

In: Journal of Molecular Evolution, Vol. 57, No. 1, 01.07.2003, p. 110-129.

Research output: Contribution to journalArticle

Fry, BG, Wüster, W, Kini, RM, Brusic, V, Khan, A, Venkataraman, D & Rooney, AP 2003, 'Molecular evolution and phylogeny of elapid snake venom three-finger toxins', Journal of Molecular Evolution, vol. 57, no. 1, pp. 110-129. https://doi.org/10.1007/s00239-003-2461-2
Fry BG, Wüster W, Kini RM, Brusic V, Khan A, Venkataraman D et al. Molecular evolution and phylogeny of elapid snake venom three-finger toxins. Journal of Molecular Evolution. 2003 Jul 1;57(1):110-129. https://doi.org/10.1007/s00239-003-2461-2
Fry, Bryan Grieg ; Wüster, W. ; Kini, R. M. ; Brusic, V. ; Khan, A. ; Venkataraman, D. ; Rooney, A. P. / Molecular evolution and phylogeny of elapid snake venom three-finger toxins. In: Journal of Molecular Evolution. 2003 ; Vol. 57, No. 1. pp. 110-129.
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