Multicolor nanoprobes based on silica-coated gadolinium oxide nanoparticles with highly reduced toxicity

Timur Sh Atabaev, Jong Ho Lee, Dong Wook Han, Ki Seok Choo, Ung Bae Jeon, Jae Yeon Hwang, Jeong A. Yeom, Chul Hee Kang, Hyung Kook Kim, Yoon Hwae Hwang

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20 Citations (Scopus)

Abstract

In recent years, multimodal contrast agents have attracted considerable attention in biomedical imaging. This paper reports the development of a multimodal nanoprobe based on silica-coated gadolinium oxide nanoparticles (NPs) for T1-enhanced magnetic resonance (MR) and multicolor optical imaging. MR relaxivity measurements showed that these core-shell NPs could generate strong positive contrast enhancement in T1-weighted MR imaging (MRI). Owing to the nominally co-doped Eu3+ and Tb3+ ions in the Gd2O3 host, the synthesized nanoprobes could simultaneously emit blue, green and red fluorescence signals. Furthermore, the cytotoxicity results showed that a thin silica coating on the surface of gadolinium oxide NPs could increase the biocompatibility of the fabricated nanoprobes considerably. The excellent multicolor fluorescence and MRI functionalities of these nanoprobes could have potential biomedical applications.

Original languageEnglish
Pages (from-to)19758-19762
Number of pages5
JournalRSC Advances
Volume6
Issue number24
DOIs
Publication statusPublished - 2016
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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    Atabaev, T. S., Lee, J. H., Han, D. W., Choo, K. S., Jeon, U. B., Hwang, J. Y., Yeom, J. A., Kang, C. H., Kim, H. K., & Hwang, Y. H. (2016). Multicolor nanoprobes based on silica-coated gadolinium oxide nanoparticles with highly reduced toxicity. RSC Advances, 6(24), 19758-19762. https://doi.org/10.1039/c5ra27685c