Multiple-layer coating of solids with impermeable film dispersing permeable particles for controlled release

Ryusei Ito, Boris Golman, Kunio Shinohara

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

For precise control of the release rate for fertilizers, pharmaceuticals, etc., the release characteristics were investigated by preparing active core particles coated with multiple layers of insoluble but permeable particles dispersed inside impermeable wax. The release profiles were described by a mathematical model which was successfully verified with experimental data. The two release stages were taken into account; the initial stage corresponds to a constant concentration of the inner solution during the existence of the solid core, and the final stage to a decreasing inner concentration with the elapse of time without the core. As a result, the low release rate was attained by involving the layer of a low volume fraction of permeable particles most closely to the core or by a thicker layer. Also, the effect of the layer thickness was verified to be lower than that of the volume fraction. Thus, the present results confirmed the potentiality of the multiple layer coating to achieve the desired release rate characteristics by choosing the proper combination of the volume fraction of permeable particles, the layer thickness and the position of the layer.

Original languageEnglish
Pages (from-to)496-502
Number of pages7
JournalJournal of Chemical Engineering of Japan
Volume37
Issue number4
DOIs
Publication statusPublished - Apr 2004
Externally publishedYes

Fingerprint

Volume fraction
Coatings
Waxes
Fertilizers
Drug products
Mathematical models
Pharmaceutical Preparations

Keywords

  • Controlled release
  • Mass transfer coefficient
  • Mathematical model
  • Multiple-layer coating
  • Permeable particles

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Multiple-layer coating of solids with impermeable film dispersing permeable particles for controlled release. / Ito, Ryusei; Golman, Boris; Shinohara, Kunio.

In: Journal of Chemical Engineering of Japan, Vol. 37, No. 4, 04.2004, p. 496-502.

Research output: Contribution to journalArticle

@article{adf2455f82c4480db5bee33cfc85059c,
title = "Multiple-layer coating of solids with impermeable film dispersing permeable particles for controlled release",
abstract = "For precise control of the release rate for fertilizers, pharmaceuticals, etc., the release characteristics were investigated by preparing active core particles coated with multiple layers of insoluble but permeable particles dispersed inside impermeable wax. The release profiles were described by a mathematical model which was successfully verified with experimental data. The two release stages were taken into account; the initial stage corresponds to a constant concentration of the inner solution during the existence of the solid core, and the final stage to a decreasing inner concentration with the elapse of time without the core. As a result, the low release rate was attained by involving the layer of a low volume fraction of permeable particles most closely to the core or by a thicker layer. Also, the effect of the layer thickness was verified to be lower than that of the volume fraction. Thus, the present results confirmed the potentiality of the multiple layer coating to achieve the desired release rate characteristics by choosing the proper combination of the volume fraction of permeable particles, the layer thickness and the position of the layer.",
keywords = "Controlled release, Mass transfer coefficient, Mathematical model, Multiple-layer coating, Permeable particles",
author = "Ryusei Ito and Boris Golman and Kunio Shinohara",
year = "2004",
month = "4",
doi = "10.1252/jcej.37.496",
language = "English",
volume = "37",
pages = "496--502",
journal = "Journal of Chemical Engineering of Japan",
issn = "0021-9592",
publisher = "Society of Chemical Engineers, Japan",
number = "4",

}

TY - JOUR

T1 - Multiple-layer coating of solids with impermeable film dispersing permeable particles for controlled release

AU - Ito, Ryusei

AU - Golman, Boris

AU - Shinohara, Kunio

PY - 2004/4

Y1 - 2004/4

N2 - For precise control of the release rate for fertilizers, pharmaceuticals, etc., the release characteristics were investigated by preparing active core particles coated with multiple layers of insoluble but permeable particles dispersed inside impermeable wax. The release profiles were described by a mathematical model which was successfully verified with experimental data. The two release stages were taken into account; the initial stage corresponds to a constant concentration of the inner solution during the existence of the solid core, and the final stage to a decreasing inner concentration with the elapse of time without the core. As a result, the low release rate was attained by involving the layer of a low volume fraction of permeable particles most closely to the core or by a thicker layer. Also, the effect of the layer thickness was verified to be lower than that of the volume fraction. Thus, the present results confirmed the potentiality of the multiple layer coating to achieve the desired release rate characteristics by choosing the proper combination of the volume fraction of permeable particles, the layer thickness and the position of the layer.

AB - For precise control of the release rate for fertilizers, pharmaceuticals, etc., the release characteristics were investigated by preparing active core particles coated with multiple layers of insoluble but permeable particles dispersed inside impermeable wax. The release profiles were described by a mathematical model which was successfully verified with experimental data. The two release stages were taken into account; the initial stage corresponds to a constant concentration of the inner solution during the existence of the solid core, and the final stage to a decreasing inner concentration with the elapse of time without the core. As a result, the low release rate was attained by involving the layer of a low volume fraction of permeable particles most closely to the core or by a thicker layer. Also, the effect of the layer thickness was verified to be lower than that of the volume fraction. Thus, the present results confirmed the potentiality of the multiple layer coating to achieve the desired release rate characteristics by choosing the proper combination of the volume fraction of permeable particles, the layer thickness and the position of the layer.

KW - Controlled release

KW - Mass transfer coefficient

KW - Mathematical model

KW - Multiple-layer coating

KW - Permeable particles

UR - http://www.scopus.com/inward/record.url?scp=3042690578&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042690578&partnerID=8YFLogxK

U2 - 10.1252/jcej.37.496

DO - 10.1252/jcej.37.496

M3 - Article

AN - SCOPUS:3042690578

VL - 37

SP - 496

EP - 502

JO - Journal of Chemical Engineering of Japan

JF - Journal of Chemical Engineering of Japan

SN - 0021-9592

IS - 4

ER -