MXene Sorbents for Removal of Urea from Dialysate

A Step toward the Wearable Artificial Kidney

Fayan Meng, Mykola Seredych, Chi Chen, Victor Gura, Sergey Mikhalovsky, Susan Sandeman, Ganesh Ingavle, Tochukwu Ozulumba, Ling Miao, Babak Anasori, Yury Gogotsi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The wearable artificial kidney can deliver continuous ambulatory dialysis for more than 3 million patients with end-stage renal disease. However, the efficient removal of urea is a key challenge in miniaturizing the device and making it light and small enough for practical use. Here, we show that two-dimensional titanium carbide (MXene) with the composition of Ti3C2Tx, where Tx represents surface termination groups such as -OH, -O-, and -F, can adsorb urea, reaching 99% removal efficiency from aqueous solution and 94% from dialysate at the initial urea concentration of 30 mg/dL, with the maximum urea adsorption capacity of 10.4 mg/g at room temperature. When tested at 37 °C, we achieved a 2-fold increase in urea removal efficiency from dialysate, with the maximum urea adsorption capacity of 21.7 mg/g. Ti3C2Tx showed good hemocompatibility; it did not induce cell apoptosis or reduce the metabolizing cell fraction, indicating no impact on cell viability at concentrations of up to 200 μg/mL. The biocompatibility of Ti3C2Tx and its selectivity for urea adsorption from dialysate open a new opportunity in designing a miniaturized dialysate regeneration system for a wearable artificial kidney.

Original languageEnglish
JournalACS Nano
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

sorbents
Dialysis Solutions
kidneys
Sorbents
ureas
Urea
Adsorption
adsorption
titanium carbides
dialysis
Titanium carbide
Dialysis
apoptosis
biocompatibility
Cell death
cells
regeneration
Biocompatibility
viability
selectivity

Keywords

  • 2D materials
  • adsorption
  • dialysate
  • MXenes
  • urea
  • wearable artificial kidney

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Meng, F., Seredych, M., Chen, C., Gura, V., Mikhalovsky, S., Sandeman, S., ... Gogotsi, Y. (Accepted/In press). MXene Sorbents for Removal of Urea from Dialysate: A Step toward the Wearable Artificial Kidney. ACS Nano. https://doi.org/10.1021/acsnano.8b06494

MXene Sorbents for Removal of Urea from Dialysate : A Step toward the Wearable Artificial Kidney. / Meng, Fayan; Seredych, Mykola; Chen, Chi; Gura, Victor; Mikhalovsky, Sergey; Sandeman, Susan; Ingavle, Ganesh; Ozulumba, Tochukwu; Miao, Ling; Anasori, Babak; Gogotsi, Yury.

In: ACS Nano, 01.01.2018.

Research output: Contribution to journalArticle

Meng, F, Seredych, M, Chen, C, Gura, V, Mikhalovsky, S, Sandeman, S, Ingavle, G, Ozulumba, T, Miao, L, Anasori, B & Gogotsi, Y 2018, 'MXene Sorbents for Removal of Urea from Dialysate: A Step toward the Wearable Artificial Kidney', ACS Nano. https://doi.org/10.1021/acsnano.8b06494
Meng, Fayan ; Seredych, Mykola ; Chen, Chi ; Gura, Victor ; Mikhalovsky, Sergey ; Sandeman, Susan ; Ingavle, Ganesh ; Ozulumba, Tochukwu ; Miao, Ling ; Anasori, Babak ; Gogotsi, Yury. / MXene Sorbents for Removal of Urea from Dialysate : A Step toward the Wearable Artificial Kidney. In: ACS Nano. 2018.
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