Nanoporous activated carbon beads and monolithic columns as effective hemoadsorbents for inflammatory cytokines

Carol A. Howell, Susan R. Sandeman, Gary J. Phillips, Sergey V. Mikhalovsky, Stephen R. Tennison, Anthony P. Rawlinson, Oleksandr P. Kozynchenko

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The aim of the present study was to develop and investigate nanoporous activated carbon materials for their ability to adsorb inflammatory cytokines directly from blood, for a range of therapeutic applications, including: systemic inflammatory response syndrome (SIRS) related to sepsis, cardiopulmonary by-pass surgery, or ischemic reperfusion injury. Building on the previously established relationship between the porous structure of beaded polymer-derived activated carbon and its capacity to adsorb inflammatory molecules, we have developed and characterized monolithic porous carbon columns produced from the same polymer precursor matrix as carbon microbeads. The monolithic columns developed were assessed for their ability to adsorb inflammatory molecules from blood in a circulating system. Preliminary findings demonstrated good removal of the inflammatory cytokines IL-8 (100% removal), IL-6 (80% removal), and TNF (51% removal) from blood. The efficiency of cleansing is dependent on the size of the adsorbed molecule and the porous structure of the monolith, highlighting their potential for use as a hemoadsorption device.

Original languageEnglish
Pages (from-to)624-632
Number of pages9
JournalInternational Journal of Artificial Organs
Volume36
Issue number9
DOIs
Publication statusPublished - Sep 2013

Fingerprint

Activated carbon
Blood
Carbon
Cytokines
Molecules
Polymers
Interleukin-8
Systemic Inflammatory Response Syndrome
Surgery
Interleukin-6
Reperfusion Injury
Microspheres
Sepsis
Equipment and Supplies
Therapeutics

Keywords

  • Activated charcoal
  • Cytokines
  • Extracorporeal circulation
  • Porosity

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Bioengineering
  • Medicine (miscellaneous)

Cite this

Howell, C. A., Sandeman, S. R., Phillips, G. J., Mikhalovsky, S. V., Tennison, S. R., Rawlinson, A. P., & Kozynchenko, O. P. (2013). Nanoporous activated carbon beads and monolithic columns as effective hemoadsorbents for inflammatory cytokines. International Journal of Artificial Organs, 36(9), 624-632. https://doi.org/10.5301/ijao.5000231

Nanoporous activated carbon beads and monolithic columns as effective hemoadsorbents for inflammatory cytokines. / Howell, Carol A.; Sandeman, Susan R.; Phillips, Gary J.; Mikhalovsky, Sergey V.; Tennison, Stephen R.; Rawlinson, Anthony P.; Kozynchenko, Oleksandr P.

In: International Journal of Artificial Organs, Vol. 36, No. 9, 09.2013, p. 624-632.

Research output: Contribution to journalArticle

Howell, CA, Sandeman, SR, Phillips, GJ, Mikhalovsky, SV, Tennison, SR, Rawlinson, AP & Kozynchenko, OP 2013, 'Nanoporous activated carbon beads and monolithic columns as effective hemoadsorbents for inflammatory cytokines', International Journal of Artificial Organs, vol. 36, no. 9, pp. 624-632. https://doi.org/10.5301/ijao.5000231
Howell, Carol A. ; Sandeman, Susan R. ; Phillips, Gary J. ; Mikhalovsky, Sergey V. ; Tennison, Stephen R. ; Rawlinson, Anthony P. ; Kozynchenko, Oleksandr P. / Nanoporous activated carbon beads and monolithic columns as effective hemoadsorbents for inflammatory cytokines. In: International Journal of Artificial Organs. 2013 ; Vol. 36, No. 9. pp. 624-632.
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