Natural (tryptophan) metabolites-mediated activation of aryl hydrocarbon receptor inhibits cancer stem cell signaling

What does it mean to prevent cancer recurrence?

Yingqiu Xie, Tursonjan Tokay, Zhaxybay Zhumadilov, Denglong Wu, Jinfu Zhang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Environmental pollutes and toxicants have long been believed as the drivers for cancer initiation and progression. The aryl hydrocarbon receptor (AhR) is one of the master regulators of the metabolism of the environmental toxicants in the cells. The AhR ligands which act as agonist have been identified in a broad range such as air pollutes of Dioxin (also called TCDD) in mist, Polycyclic aromatic hydrocarbon found in soil and particulate matter suspended in air, benzoapyrene found in atmospheric wood burning, indigo dye and dietary carotenoids (1). Ligand bound AhR can be released from HSP90-AhR complex and enter into the nucleus. As a transcription factor with basic helix-loop-helix/Per-Arnt-Sim (bHLH-PAS) domains, AhR nuclear translocation can promote transcription of several genes whose encoding proteins catalyze the metabolism and conjugation of xenobiotics or carcinogens such as CYP1A1 in which gene promoter embeds dioxin response elements (DREs) (1).

Original languageEnglish
Pages (from-to)64-67
Number of pages4
JournalTranslational Cancer Research
Volume5
Issue number1
DOIs
Publication statusPublished - Feb 1 2016

Fingerprint

Aryl Hydrocarbon Receptors
Neoplastic Stem Cells
Tryptophan
Recurrence
Dioxins
Neoplasms
Air
Indigo Carmine
Ligands
Basic Helix-Loop-Helix Transcription Factors
Cytochrome P-450 CYP1A1
Particulate Matter
Polycyclic Aromatic Hydrocarbons
Response Elements
Xenobiotics
Carotenoids
Carcinogens
Genes
Coloring Agents
Soil

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

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abstract = "Environmental pollutes and toxicants have long been believed as the drivers for cancer initiation and progression. The aryl hydrocarbon receptor (AhR) is one of the master regulators of the metabolism of the environmental toxicants in the cells. The AhR ligands which act as agonist have been identified in a broad range such as air pollutes of Dioxin (also called TCDD) in mist, Polycyclic aromatic hydrocarbon found in soil and particulate matter suspended in air, benzoapyrene found in atmospheric wood burning, indigo dye and dietary carotenoids (1). Ligand bound AhR can be released from HSP90-AhR complex and enter into the nucleus. As a transcription factor with basic helix-loop-helix/Per-Arnt-Sim (bHLH-PAS) domains, AhR nuclear translocation can promote transcription of several genes whose encoding proteins catalyze the metabolism and conjugation of xenobiotics or carcinogens such as CYP1A1 in which gene promoter embeds dioxin response elements (DREs) (1).",
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AU - Wu, Denglong

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