Neuralized functions cell autonomously to regulate Drosophila sense organ development

Edward Yeh, Lily Zhou, Nicholas Rudzik, Gabrielle L. Boulianne

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Neurogenic genes, including Notch and Delta, are thought to play important roles in regulating cell-cell interactions required for Drosophila sense organ development. To define the requirement of the neurogenic gene neuralized (neu) in this process, two independent neu alleles were used to generate mutant clones. We find that neu is required for determination of cell fates within the proneural cluster and that cells mutant for neu autonomously adopt neural fates when adjacent to wild-type cells. Furthermore, neu is required within the sense organ lineage to determine the fates of daughter cells and accessory cells. To gain insight into the mechanism by which neu functions, we used the GAL4/UAS system to express wild-type and epitope-tagged neu constructs. We show that Neu protein is localized primarily at the plasma membrane. We propose that the function of neu in sense organ development is to affect the ability of cells to receive Notch-Delta signals and thus modulate neurogenic activity that allows for the specification of non-neuronal cell fates in the sense organ.

Original languageEnglish
Pages (from-to)4827-4837
Number of pages11
JournalEMBO Journal
Volume19
Issue number17
Publication statusPublished - Sep 1 2000
Externally publishedYes

Fingerprint

Sense Organs
Drosophila
Genes
Accessories
Cell membranes
Epitopes
Specifications
Proteins
Cell Communication
Clone Cells
Alleles
Cell Membrane

Keywords

  • Drosophila
  • Neuralized
  • Neurogenesis
  • Sense organ

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

Cite this

Yeh, E., Zhou, L., Rudzik, N., & Boulianne, G. L. (2000). Neuralized functions cell autonomously to regulate Drosophila sense organ development. EMBO Journal, 19(17), 4827-4837.

Neuralized functions cell autonomously to regulate Drosophila sense organ development. / Yeh, Edward; Zhou, Lily; Rudzik, Nicholas; Boulianne, Gabrielle L.

In: EMBO Journal, Vol. 19, No. 17, 01.09.2000, p. 4827-4837.

Research output: Contribution to journalArticle

Yeh, E, Zhou, L, Rudzik, N & Boulianne, GL 2000, 'Neuralized functions cell autonomously to regulate Drosophila sense organ development', EMBO Journal, vol. 19, no. 17, pp. 4827-4837.
Yeh E, Zhou L, Rudzik N, Boulianne GL. Neuralized functions cell autonomously to regulate Drosophila sense organ development. EMBO Journal. 2000 Sep 1;19(17):4827-4837.
Yeh, Edward ; Zhou, Lily ; Rudzik, Nicholas ; Boulianne, Gabrielle L. / Neuralized functions cell autonomously to regulate Drosophila sense organ development. In: EMBO Journal. 2000 ; Vol. 19, No. 17. pp. 4827-4837.
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