Neutrophil gelatinase-associated lipocalin in prediction of mortality in patients with hepatorenal syndrome: A prospective observational study

Gokhan Gungor, Huseyin Ataseven, Ali Demir, Yalcin Solak, Abduzhappar Gaipov, Murat Biyik, Bahadir Ozturk, Ilker Polat, Aysel Kiyici, Ozlem O. Cakir, Hakki Polat

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background & Aims: Hepatorenal syndrome (HRS) is a severe complication of cirrhosis which is characterized by renal dysfunction and associated with poor survival. Neutrophil gelatinase-associated lipocalin (NGAL) is a troponin-like biomarker for human acute kidney injury. We aimed to investigate levels of plasma and urine NGAL in HRS and predictive ability of these markers for all-cause mortality, in HRS, stable cirrhosis and control subjects. Methods: A total of 64 patients with cirrhosis (8 patients with type 1 HRS, 22 with type 2 HRS, and 34 without HRS) and 23 control subjects were included in the study. Blood and urine samples were measured with Human NGAL sandwich ELISA. Patients were followed up prospectively. Results: Patients with type 1 and type 2 HRS had significantly higher plasma and urine NGAL levels compared with stable cirrhosis and control subjects. Cox regression analysis showed that plasma NGAL and MELD-Na scores were independent predictors of mortality. ROC-curve analysis showed that the plot of the plasma NGAL, urine NGAL, MELD-Na and Child-Turcot-Pugh score could predict all-cause mortality in cirrhotic patients' area under the curve (AUC 0.819, 0.686, 0.807 and 0.795 respectively). Conclusions: NGAL could predict mortality in patients with HRS independent of other commonly used risk factors.

Original languageEnglish
Pages (from-to)49-57
Number of pages9
JournalLiver International
Volume34
Issue number1
DOIs
Publication statusPublished - Jan 1 2014
Externally publishedYes

Keywords

  • Acute kidney injury
  • Cirrhosis
  • Hepatorenal syndrome
  • Mortality
  • Neutrophil gelatinase-associated lipocalin

ASJC Scopus subject areas

  • Hepatology

Fingerprint Dive into the research topics of 'Neutrophil gelatinase-associated lipocalin in prediction of mortality in patients with hepatorenal syndrome: A prospective observational study'. Together they form a unique fingerprint.

  • Cite this

    Gungor, G., Ataseven, H., Demir, A., Solak, Y., Gaipov, A., Biyik, M., Ozturk, B., Polat, I., Kiyici, A., Cakir, O. O., & Polat, H. (2014). Neutrophil gelatinase-associated lipocalin in prediction of mortality in patients with hepatorenal syndrome: A prospective observational study. Liver International, 34(1), 49-57. https://doi.org/10.1111/liv.12232