TY - JOUR
T1 - nMet, a new target in recurrent cancer
AU - Xie, Yingqiu
AU - Istayeva, Sholpan
AU - Chen, Zhanlin
AU - Tokay, Tursonjan
AU - Zhumadilov, Zhaxybay
AU - Wu, Denglong
AU - Hortelano, Gonzalo
AU - Zhang, Jinfu
N1 - Publisher Copyright:
© 2016 Bentham Science Publishers.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Membranous Met is classically identified with its role in cancer metastases, while nuclear Met is associated with a more invasive, aggressive and proliferative form of cancer. Full-length Met or N-terminal transmembrane domain cleaved Met can translocate into nucleus in a cell growth and pH dependent but both ligand-dependent (full length Met) and -independent (cleaved Met) manner. nMET may play greater essential roles in cancer recurrence than membranous Met. For example, in prostate cancer, it has been found that androgen receptor (AR) may inhibit the expression of membranous Met so anti-androgen based prostate cancer therapy may promote the expression of nuclear Met (nMET). We recently found a novel nMET/SOX9/ β-Catenin/AR pathway in relapsed prostate cancer which may contribute to the formation of the feedback loop of AR reactivation via MET/nMET. Emerging evidence suggests the possibility of nMET as a prognostic marker in relapsed cancer. This review summarizes recent findings about nMET and its unique role in recurrent cancer.
AB - Membranous Met is classically identified with its role in cancer metastases, while nuclear Met is associated with a more invasive, aggressive and proliferative form of cancer. Full-length Met or N-terminal transmembrane domain cleaved Met can translocate into nucleus in a cell growth and pH dependent but both ligand-dependent (full length Met) and -independent (cleaved Met) manner. nMET may play greater essential roles in cancer recurrence than membranous Met. For example, in prostate cancer, it has been found that androgen receptor (AR) may inhibit the expression of membranous Met so anti-androgen based prostate cancer therapy may promote the expression of nuclear Met (nMET). We recently found a novel nMET/SOX9/ β-Catenin/AR pathway in relapsed prostate cancer which may contribute to the formation of the feedback loop of AR reactivation via MET/nMET. Emerging evidence suggests the possibility of nMET as a prognostic marker in relapsed cancer. This review summarizes recent findings about nMET and its unique role in recurrent cancer.
KW - Met
KW - Nuclear translocation
KW - Oncogene
KW - Recurrence
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U2 - 10.2174/1568009616666160105105250
DO - 10.2174/1568009616666160105105250
M3 - Review article
C2 - 26728040
AN - SCOPUS:84986888464
SN - 1568-0096
VL - 16
SP - 572
EP - 578
JO - Current Cancer Drug Targets
JF - Current Cancer Drug Targets
IS - 7
ER -