Noninvasive measurement of scleral stiffness and tangent modulus in porcine eyes

Leo K.K. Leung, Match W.L. Ko, Cong Ye, David C.C. Lam, Christopher K.S. Leung

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Purpose. We investigated an indentation technique to measure the scleral stiffness and tangent modulus of porcine eyes. Methods. The scleral load-displacement responses were measured with a universal testing machine as a function of IOP in 15 porcine eyes ex vivo using a 5-mm diameter cylindrical flat-punch indenter. The scleral radius of curvature and scleral thickness were measured using a DSLR camera (Alpha 900) and a camera-mounted stereomicroscope (M205C), respectively. The relationships between scleral stiffness, tangent modulus, and IOP were examined. Results. The mean local scleral radius of curvature and scleral thickness were 7.86 ± 0.49 and 1.03 ± 0.14 mm, respectively. The average scleral stiffness and scleral tangent modulus of porcine eyes were 0.13 ± 0.02 N/mm and 0.20 ± 0.04 MPa at 15 mm Hg, respectively. The scleral stiffness and scleral tangent modulus were correlated positively with IOP (scleral stiffness, 0.989 < r < 0.999, P < 0.001; scleral tangent modulus, 0.989 < r < 0.999, P < 0.001). Conclusions. The scleral indentation technique can provide a noninvasive approach to measure scleral stiffness and tangent modulus.

Original languageEnglish
Pages (from-to)3721-3726
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Volume55
Issue number6
DOIs
Publication statusPublished - May 15 2014

Keywords

  • Glaucoma
  • Myopia
  • Noninvasive measurement
  • Sclera
  • Tangent modulus

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Noninvasive measurement of scleral stiffness and tangent modulus in porcine eyes'. Together they form a unique fingerprint.

Cite this