Nonlinear contrast imaging with an array-based micro-ultrasound system

A. Needles, M. Arditi, N. G. Rognin, J. Mehi, T. Coulthard, C. Bilan-Tracey, E. Gaud, P. Frinking, D. Hirson, F. S. Foster

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

The main goal of this study was to determine the optimal strategy for a real-time nonlinear contrast mode for small-animal imaging at high frequencies, on a new array-based micro-ultrasound system. Previously reported contrast imaging at frequencies above 15 MHz has primarily relied on subtraction schemes involving B-mode image data. These approaches provide insufficient contrast to tissue ratios under many imaging conditions. In this work, pulse inversion, amplitude modulation and combinations of these were systematically investigated for the detection of nonlinear fundamental and subharmonic signal components to maximize contrast-to-tissue ratio (CTR) in the 18-24 MHz range. From in vitro and in vivo measurements, nonlinear fundamental detection with amplitude modulation provided optimal results, allowing an improvement in CTR of 13 dB compared with fundamental imaging. Based on this detection scheme, in vivo parametric images of murine kidneys were generated using sequences of nonlinear contrast images after intravenous bolus injections of microbubble suspensions. Initial parametric images of peak enhancement (PE), wash-in rate (WiR) and rise time (RT) are presented. The parametric images are indicative of blood perfusion kinetics, which, in the context of preclinical imaging with small animals, are anticipated to provide valuable insights into the progression of human disease models, where blood perfusion plays a critical role in either the diagnosis or treatment of the disease.

Original languageEnglish
Pages (from-to)2097-2106
Number of pages10
JournalUltrasound in Medicine and Biology
Volume36
Issue number12
DOIs
Publication statusPublished - Dec 2010
Externally publishedYes

Fingerprint

Perfusion
Image Enhancement
Microbubbles
Hematologic Diseases
blood
animals
Intravenous Injections
Disease Progression
Suspensions
Kidney
kidneys
image contrast
subtraction
progressions
inversions
injection
augmentation
kinetics
pulses
Therapeutics

Keywords

  • Blood perfusion
  • Contrast-enhanced ultrasound
  • High frequency
  • Micro-ultrasound
  • Microbubble
  • Mouse
  • Nonlinear microbubble detection
  • Parametric imaging
  • Small animal

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics

Cite this

Needles, A., Arditi, M., Rognin, N. G., Mehi, J., Coulthard, T., Bilan-Tracey, C., ... Foster, F. S. (2010). Nonlinear contrast imaging with an array-based micro-ultrasound system. Ultrasound in Medicine and Biology, 36(12), 2097-2106. https://doi.org/10.1016/j.ultrasmedbio.2010.08.012

Nonlinear contrast imaging with an array-based micro-ultrasound system. / Needles, A.; Arditi, M.; Rognin, N. G.; Mehi, J.; Coulthard, T.; Bilan-Tracey, C.; Gaud, E.; Frinking, P.; Hirson, D.; Foster, F. S.

In: Ultrasound in Medicine and Biology, Vol. 36, No. 12, 12.2010, p. 2097-2106.

Research output: Contribution to journalArticle

Needles, A, Arditi, M, Rognin, NG, Mehi, J, Coulthard, T, Bilan-Tracey, C, Gaud, E, Frinking, P, Hirson, D & Foster, FS 2010, 'Nonlinear contrast imaging with an array-based micro-ultrasound system', Ultrasound in Medicine and Biology, vol. 36, no. 12, pp. 2097-2106. https://doi.org/10.1016/j.ultrasmedbio.2010.08.012
Needles A, Arditi M, Rognin NG, Mehi J, Coulthard T, Bilan-Tracey C et al. Nonlinear contrast imaging with an array-based micro-ultrasound system. Ultrasound in Medicine and Biology. 2010 Dec;36(12):2097-2106. https://doi.org/10.1016/j.ultrasmedbio.2010.08.012
Needles, A. ; Arditi, M. ; Rognin, N. G. ; Mehi, J. ; Coulthard, T. ; Bilan-Tracey, C. ; Gaud, E. ; Frinking, P. ; Hirson, D. ; Foster, F. S. / Nonlinear contrast imaging with an array-based micro-ultrasound system. In: Ultrasound in Medicine and Biology. 2010 ; Vol. 36, No. 12. pp. 2097-2106.
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